NDLI: Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

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Toxicology Research Vol -6

Toxicology Research Vol -5

Toxicology Research Vol - 5 Issue - 6

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Contents list

Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data

Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene

Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane

Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO₂, NO₂ and PM_2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway

Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis

Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model

Resveratrol and pterostilbene attenuated smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner

Cellular uptake, genotoxicity and cytotoxicity of cobalt ferrite magnetic nanoparticles in human breast cells

Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition

⁵⁶Fe irradiation-induced cognitive deficits through oxidative stress in mice

Alteration of mitochondrial phospholipid due to the PLA₂ activation in rat brains under cadmium toxicity

Hepatoprotective activity of viscosine is mediated by attenuation of hepatic macrophages and iNOS expression in CCl₄-intoxicated rats

Cell mechanotactic and cytotoxic response to zinc oxide nanorods depends on substrate stiffness

Effect of dietary protein or calcium supplement on the expression of collagen I and dentine phosphoprotein of rats with dental fluorosis

Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response

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Toxicology Research Vol - 5 Issue - 5

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Toxicology Research Vol - 5 Issue - 3

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Toxicology Research Vol -1

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

Content Provider	Royal Society of Chemistry (RSC)
Author	Wang, Xiangke Liu, Xinhui Cui, Baoshan Bai, Junhong Hou, Jing
Copyright Year	2016
Abstract	The evaluation of mercury (Hg) toxicity in agricultural soil is of great concern because its bioavailability and bioaccumulation in organisms through the food chain can have adverse effects on human health. Therefore, the aim of this study was to develop sensitive biomarkers for Hg stress in agricultural soil. With the results obtained from a high-throughput cDNA microarray, 12 Hg-responsive genes were selected to examine their concentration-dependent responses to Hg stress at different Hg concentrations. The lowest observable adverse effect concentrations (LOAECs) of Hg were 0.8 mg kg−1 for seed germination, 1.6 mg kg−1 for root biomass, 0.8 mg kg−1 for root elongation, and 0.8 mg kg−1 for root morphology, respectively, whereas the lowest Hg treatments (0.1–0.4 mg kg−1) could generally induce differential expression of genes. These results indicated that the detection of Hg in soil at the molecular level is a highly sensitive method. Moreover, the Hg soil content exhibited a significant positive correlation with the relative expression of probable glutathione S-transferase parA (r = 0.637, p = 0.05), chlorophyll a–b binding protein 13, chloroplastic-like (r = 0.689, p = 0.05) and geranylgeranyl pyrophosphate synthase 1 (r = 0.682, p = 0.05), implying that the three genes are good candidates to detect Hg-contaminated soil.
Starting Page	1539
Ending Page	1547
Page Count	9
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	6
Journal	Toxicology Research
DOI	10.1039/c6tx00210b
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Chlorophyll Complementary DNA Bioaccumulation Germination Methylmercury Bioavailability Biomass Microarray Glutathione S-transferase Geranylgeranyl pyrophosphate Protein
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Bioaccumulation of PCB-153 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels.

Cadmium modulates the mRNA expression and activity of glutathione S-transferase in the monogonont Rotifer Brachionus koreanus

Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels

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Bioaccumulation of 4-nonylphenol and effects on biomarkers, acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase, in Mytilus galloprovincialis mussel gilla.

Bioaccumulation of total mercury in the earthworm Eisenia andrei

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Biochemical and behavioral deficits in the lobster cockroach Nauphoeta cinerea model of methylmercury exposure

Mercury and methylmercury bioaccumulation by polychaete worms is governed by both feeding ecology and mercury bioavailability in coastal mudflats.

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

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