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Toxicology Research Vol -6

Toxicology Research Vol -5

Toxicology Research Vol - 5 Issue - 6

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Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data

Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene

Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane

Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO₂, NO₂ and PM_2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway

Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis

Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model

Resveratrol and pterostilbene attenuated smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner

Cellular uptake, genotoxicity and cytotoxicity of cobalt ferrite magnetic nanoparticles in human breast cells

Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition

⁵⁶Fe irradiation-induced cognitive deficits through oxidative stress in mice

Alteration of mitochondrial phospholipid due to the PLA₂ activation in rat brains under cadmium toxicity

Hepatoprotective activity of viscosine is mediated by attenuation of hepatic macrophages and iNOS expression in CCl₄-intoxicated rats

Cell mechanotactic and cytotoxic response to zinc oxide nanorods depends on substrate stiffness

Effect of dietary protein or calcium supplement on the expression of collagen I and dentine phosphoprotein of rats with dental fluorosis

Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response

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Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

Content Provider	Royal Society of Chemistry (RSC)
Author	Govarthanan, Muthusamy Aravinthan, Adithan Kim, Jong-Hoon Kamala-Kannan, Seralathan
Copyright Year	2016
Abstract	Background: Many in vivo studies have revealed that the cytotoxic potential of gold nanoparticles results in controversial conclusions. The aim of this study is to establish a systematic method for determining the biological effects of gold nanoparticles in rats. Methods: In the present investigation AuNPs were prepared using Helianthus tuberosus extract as a reducing agent. The synthesized AuNPs were characterized using various techniques, such as Bio-TEM, SEM-EDS, X-ray diffraction and FT-IR. Cytotoxicity of the synthesized AuNPs was assessed using the rat as an animal model. Subchronic oral administration of AuNPs (5 and 10 mg kg−1) and its effect on major organs (liver, kidney, lungs, and spleen) and its accumulation were analyzed using haematoxylin & eosin staining and ICP-MS respectively. The extent of apoptosis in the liver cells was determined using western blotting. Results: The results of the current study revealed that the synthesized AuNPs at a mild concentration of 5 mg kg−1 have been found to cause a hypoglycemic state and an increase in the HDL cholesterol level in normal rats. Nevertheless, histopathological results revealed that AuNPs could cause inflammation in the lungs at increasing concentrations. Conclusion: The biologically synthesized AuNPs were evaluated in this study showed a hypoglycemic effect at a concentration of 5 mg kg−1 AuNPs. A systemic study on the accumulation of AuNPs revealed that the lung is the major target organ and further suggests that enduring administration could lead to organ damage as majorly observed in lung tissue. This study highlights the necessity of complete in vivo toxicity analysis, prior to introducing nanoparticles in any application field. Further, this study warrants the application of the synthesized AuNPs in drug delivery related to lung disorders.
Starting Page	1530
Ending Page	1538
Page Count	9
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	6
Journal	Toxicology Research
DOI	10.1039/c6tx00202a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Spleen Western blot Blood sugar Liver Lung Redox Haematoxylin Cytotoxicity Inflammation Drug delivery Fourier-transform infrared spectroscopy Model organism Kidney Eosin X-ray crystallography High-density lipoprotein Jerusalem artichoke Apoptosis
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Biomass Accumulation and Nutrient Uptake of Jerusalem Artichoke (Helianthus tuberosus L.)

Characterization of Fructan Metabolism During Jerusalem Artichoke (Helianthus tuberosus L.) Germination

Effects of self-assembled fibers on the synthesis, characteristics and biomedical applications of CCAG hydrogels

Microscopy, giemsa and haematoxylin-eosin staining methods.

Salt stress affects the biomass of industrial crop Jerusalem artichoke by affecting sugar transport and metabolism.

Growing the Jerusalem artichoke

Growing the Jerusalem artichoke ..

Predicting of Effective Dose as Biomarker for Cytotoxicity Using Partial Least Square-Fourier Transform Infrared Spectroscopy (PLS_FTIR).

Characterization of oxidoreductase-redox polymer electrostatic film assembly on gold by surface plasmon resonance spectroscopy and Fourier transform infrared-external reflection spectroscopy

Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

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Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study