NDLI: Biochemical and behavioral deficits in the lobster cockroach Nauphoeta cinerea model of methylmercury exposure

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Biochemical and behavioral deficits in the lobster cockroach Nauphoeta cinerea model of methylmercury exposure

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Toxicology Research Vol - 4 Issue - 1

Toxicology Research Vol -3

Toxicology Research Vol -2

Toxicology Research Vol -1

Biochemical and behavioral deficits in the lobster cockroach Nauphoeta cinerea model of methylmercury exposure

Content Provider	Royal Society of Chemistry (RSC)
Author	Farombi, Ebenezer O. Adedara, Isaac A. Souza, Diogo O. Kamdem, Jean P. Rosemberg, Denis B. Aschner, Michael Rocha, Joao B. T.
Copyright Year	2015
Abstract	Methylmercury (MeHg) is well-known for its neurodevelopmental effects both in animals and in humans. As an alternative to utilizing conventional animal models, this study evaluated behavioral and biochemical parameters using the nymphs of the lobster cockroach Nauphoeta cinerea. Animals were exposed to MeHg at 0, 0.03125, 0.0625, 0.125, 0.25 and 0.5 mg per g feed for 35 consecutive days. Locomotor activity and exploratory profiles were analyzed using video-tracking software during a 10 minute trial. Subsequently, biochemical estimations were carried out using cockroach heads. MeHg exposure caused behavioral impairment as evidenced by a significant decrease in distance travelled, time spent walking, turn angle and body rotation. The marked decrease in the exploratory profiles of MeHg-exposed cockroaches was confirmed by track plots, whereas occupancy plot analyses revealed a gradual dispersal in home-base formation, starting from 0.0625 mg per g feed. Biochemically, MeHg exposure significantly decreased acetylcholinesterase activity (AChE), an enzyme which plays a pivotal role in neurotransmission. Moreover, MeHg caused increased oxidative stress as evidenced by decreased total thiol levels and glutathione S-transferase (GST) activity, along with increased 2′,7′-dichlorofluorescein (DFCH) oxidation and thiobarbituric acid reactive substance (TBARS) production. In conclusion, these data demonstrated that Nauphoeta cinerea mimics the behavioral and biochemical deficits observed in rodents exposed to MeHg, thus highlighting its validity as an alternative model for basic toxicological studies.
Starting Page	442
Ending Page	451
Page Count	10
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	4
Issue Number	2
Journal	Toxicology Research
DOI	10.1039/c4tx00231h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Oxidative stress Thiol Animal locomotion Enzyme Lipid peroxidation Acetylcholinesterase Cockroach Dichlorofluorescein Lobster Methylmercury Neurotransmitter Glutathione S-transferase
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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