NDLI: Cadmium modulates the mRNA expression and activity of glutathione S-transferase in the monogonont Rotifer Brachionus koreanus

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Cadmium modulates the mRNA expression and activity of glutathione S-transferase in the monogonont Rotifer Brachionus koreanus

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Cadmium modulates the mRNA expression and activity of glutathione S-transferase in the monogonont Rotifer Brachionus koreanus

Content Provider	Springer Nature Link
Author	Yim, Bora Kim, Hokyun Jung, Mi Young Lee, Young Mi
Copyright Year	2015
Abstract	Cadmium has adverse effects on aquatic organisms. Here, we measured the ROS level, total GSH contents and total GST activity after exposure to Cd. In addition, the mRNA expression of four GST isoforms was investigated in response to Cd using real-time RT-PCR in the monogonant rotifer, Brachionus koreanus. As results, intracellular ROS level was elevated, total GSH content was declined, and GST activity was significantly elevated in Cd-exposed group, indicating that Cd can induce oxidative stress by producing ROS, and GSH and GST may be involved in cellular protection against Cd-induced toxicity. After exposure to Cd, mRNA expression of Bk-GST isoforms was differently modulated. In particular, Bk-GST-omega mRNA level was highly sensitive to Cd exposure, indicating that this isoform play a key role in protective responses to Cd in this species and would be useful as a molecular biomarker for monitoring of heavy metal toxicity in aquatic environment.
Starting Page	217
Ending Page	223
Page Count	7
File Format	PDF
ISSN	20059752
Journal	Toxicology and Environmental Health Sciences
Volume Number	7
Issue Number	3
e-ISSN	22337784
Language	English
Publisher	Korean Society of Environmental Risk Assessment and Health Science
Publisher Date	2015-11-03
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Brachionus koreanus Cadmium Glutathione S-transferase Quantitative real-time RT-PCR Rotifer Pharmacology/Toxicology Environmental Health
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Expression profiles of heat shock protein gene families in the monogonont rotifer Brachionus koreanus — exposed to copper and cadmium

Effects of heavy metals on transcription and enzyme activity of Na$^{+}$/K$^{+}$-ATPase in the monogonont rotifer, Brachionus koreanus

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Triclosan (TCS) and Triclocarban (TCC) cause lifespan reduction and reproductive impairment through oxidative stress-mediated expression of the defensome in the monogonont rotifer (Brachionus koreanus).

Effect of copper exposure on GST activity and on the expression of four GSTs under oxidative stress condition in the monogonont rotifer, Brachionus koreanus.

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Cadmium modulates the mRNA expression and activity of glutathione S-transferase in the monogonont Rotifer Brachionus koreanus

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