NDLI: Alteration of mitochondrial phospholipid due to the PLA<sub>2</sub> activation in rat brains under cadmium toxicity

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Toxicology Research Vol -6

Toxicology Research Vol -5

Toxicology Research Vol - 5 Issue - 6

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Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data

Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene

Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane

Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO₂, NO₂ and PM_2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway

Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis

Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model

Resveratrol and pterostilbene attenuated smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner

Cellular uptake, genotoxicity and cytotoxicity of cobalt ferrite magnetic nanoparticles in human breast cells

Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition

⁵⁶Fe irradiation-induced cognitive deficits through oxidative stress in mice

Alteration of mitochondrial phospholipid due to the PLA₂ activation in rat brains under cadmium toxicity

Hepatoprotective activity of viscosine is mediated by attenuation of hepatic macrophages and iNOS expression in CCl₄-intoxicated rats

Cell mechanotactic and cytotoxic response to zinc oxide nanorods depends on substrate stiffness

Effect of dietary protein or calcium supplement on the expression of collagen I and dentine phosphoprotein of rats with dental fluorosis

Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response

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Toxicology Research Vol - 5 Issue - 5

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Toxicology Research Vol - 5 Issue - 3

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Alteration of mitochondrial phospholipid due to the PLA₂ activation in rat brains under cadmium toxicity

Content Provider	Royal Society of Chemistry (RSC)
Author	Sivaprakasam, Chinnarasu Vijayakumar, Rajendran Nachiappan, Vasanthi Arul, Mathivanan
Copyright Year	2016
Abstract	Cadmium (Cd) is a heavy metal that has received considerable environmental and occupational concern. Cd causes toxic effects due to its accumulation in a variety of tissues, including the kidney, liver and the nervous system (CNS); however, the exact mechanism is poorly understood. In the present study, we tried to explore the impact of acute cadmium exposure on rat brain phospholipids (PLs). Cd exposure significantly reduced PLs in a time dependent manner and the reduction was due to the activation of the Phospholipase A2 enzymes (sPLA2, cPLA2). The release of arachidonic acid from PLs increased during inflammatory conditions by PLA2s. The mRNA expression of cyclooxygenase2 (COX2) and subsequently the pro-inflammatory cytokines, namely, Interleukin 1 (IL-1) and IL-6, were up regulated; however, the expression of anti-inflammatory cytokine IL-10 was reduced in a time dependent manner. The expression of the Tumor necrosis factor alpha (TNF-α), Inducible nitric oxide synthase (iNOS) and Interferon gamma (INF-γ) also experienced increases in the expression. Likewise the mRNA expression of the pro-apoptotic factor, Bcl-2-associated X protein (Bax), was elevated, whereas anti-apoptosis B-cell lymphoma 2 (Bcl2) was down regulated. This present study might help to decipher the effects of cadmium toxicity on rat brain.
Starting Page	1680
Ending Page	1687
Page Count	8
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	6
Journal	Toxicology Research
DOI	10.1039/c6tx00201c
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Inducible Bcl-2 Cadmium Phospholipase A2 Interleukin Liver Central nervous system Cytokine Cytochrome c oxidase subunit II Heavy metals Kidney Protein Interleukin-1 family Interleukin 6 Tumor necrosis factor alpha Messenger RNA Bcl-2-associated X protein Interleukin 10 Nitric oxide synthase Interferon gamma B-cell lymphoma
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Lipoxygenase Products Regulate Nitric Oxide and Inducible Nitric Oxide Synthase Production in Interleukin-1β Stimulated Vascular Smooth Muscle Cells

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Alteration of mitochondrial phospholipid due to the PLA₂ activation in rat brains under cadmium toxicity

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Alteration of mitochondrial phospholipid due to the PLA2 activation in rat brains under cadmium toxicity

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