NDLI: Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

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Toxicology Research Vol -6

Toxicology Research Vol -5

Toxicology Research Vol - 5 Issue - 6

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Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data

Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene

Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane

Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO₂, NO₂ and PM_2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway

Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis

Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model

Resveratrol and pterostilbene attenuated smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner

Cellular uptake, genotoxicity and cytotoxicity of cobalt ferrite magnetic nanoparticles in human breast cells

Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition

⁵⁶Fe irradiation-induced cognitive deficits through oxidative stress in mice

Alteration of mitochondrial phospholipid due to the PLA₂ activation in rat brains under cadmium toxicity

Hepatoprotective activity of viscosine is mediated by attenuation of hepatic macrophages and iNOS expression in CCl₄-intoxicated rats

Cell mechanotactic and cytotoxic response to zinc oxide nanorods depends on substrate stiffness

Effect of dietary protein or calcium supplement on the expression of collagen I and dentine phosphoprotein of rats with dental fluorosis

Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response

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Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

Content Provider	Royal Society of Chemistry (RSC)
Author	Lima, Marta L. Toledo, Juliano S. Fernandes, Paula A. Aguiar, Marta M. G. Ferreira, Lucas A. M. Fernandes, Ana Paula Santos, Délia C. M. López-Gonzálvez, Ángeles Barbas, Coral
Copyright Year	2016
Abstract	Amphotericin B (AmB) is a drug of choice against life-threatening systemic fungal infections and an alternative therapy for the treatment of all forms of leishmaniasis. It is known that AmB and its conventional formulation cause renal damage; however, the lipid formulations can reduce these effects. The aim of the present study was to identify metabolic changes in mice treated with two different AmB formulations, a nanoemulsion (NE) (lipid system carrier) loaded with AmB and the conventional formulation (C-AmB). For this purpose, metabolic fingerprinting represents a valuable strategy to monitor, in a non-targeted manner, the changes that are at the base of the toxicity mechanism of AmB. Plasma samples of BALB-c mice were collected after treatment with 3 alternate doses of AmB at 1 mg kg−1 administered intravenously and analysed with CE, LC and GC coupled to MS. Blood urea nitrogen (BUN) and plasma creatinine levels were also analysed. Kidney tissue specimens were collected and evaluated. It was not observed that there were any alterations in BUN and creatinine levels as well as in histopathological analysis. Approximately 30 metabolites were identified as potentially related to early C-AmB-induced nephrotoxicity. Disturbances in the arachidonic acid, glycerophospholipid, acylcarnitine and polyunsaturated fatty acid (PUFA) pathways were observed in C-AmB-treated mice. In the AmB-loaded NE group, it was observed that there were fewer metabolic changes, including changes in the plasma levels of cortisol and pyranose. The candidate biomarkers revealed in this study could be useful in the detection of the onset and severity of kidney injury induced by AmB formulations.
Starting Page	1720
Ending Page	1732
Page Count	13
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	6
Journal	Toxicology Research
DOI	10.1039/c6tx00253f
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Creatinine Renal function Pyranose Cortisol Leishmaniasis The Candidate (1972 film) Lipid Blood plasma Amphotericin B Glycerophospholipid Fatty acid AmB Blood urea nitrogen Nephrotoxicity
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Comparison of Amphotericin B Lipid Complex (Abelcet) and Liposomal Amphotericin B (Ambisome) on Rat Kidney: a Morphological Evaluation

Case Report: Use of Liposomal Amphotericin B in Low Doses in Patients With Visceral Leishmaniasis

An Evaluation of Hepatotoxicity and Nephrotoxicity of Liposomal Amphotericin B (L-AMB)

An Evaluation of Hepatotoxicity and Nephrotoxicity of Liposomal Amphotericin B (L-AMB)

Comparison of Amphotericin B Lipid Complex (Abelcet) and Liposomal Amphotericin B (Ambisome) on Rat Kidney: a Morphological Evaluation

Original article cisplatin nephrotoxicity and protection by milk thistle extract in rats.

In-vitro and in-vivo antileishmanial activity of inexpensive Amphotericin B formulations: Heated Amphotericin B and Amphotericin B-loaded microemulsion.

An Evaluation of Hepatotoxicity and Nephrotoxicity of Liposomal Amphotericin B (L-AMB)

Safety of different amphotericin B formulations among AIDS patients with invasive fungal disease: a retrospective observational study

Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

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