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Toxicology Research Vol -6

Toxicology Research Vol -5

Toxicology Research Vol - 5 Issue - 6

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Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data

Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene

Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane

Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO₂, NO₂ and PM_2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway

Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis

Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model

Resveratrol and pterostilbene attenuated smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner

Cellular uptake, genotoxicity and cytotoxicity of cobalt ferrite magnetic nanoparticles in human breast cells

Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition

⁵⁶Fe irradiation-induced cognitive deficits through oxidative stress in mice

Alteration of mitochondrial phospholipid due to the PLA₂ activation in rat brains under cadmium toxicity

Hepatoprotective activity of viscosine is mediated by attenuation of hepatic macrophages and iNOS expression in CCl₄-intoxicated rats

Cell mechanotactic and cytotoxic response to zinc oxide nanorods depends on substrate stiffness

Effect of dietary protein or calcium supplement on the expression of collagen I and dentine phosphoprotein of rats with dental fluorosis

Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response

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Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response

Content Provider	Royal Society of Chemistry (RSC)
Author	Braydich-Stolle, Laura K. Hill, Natasha T. Sakaram, Suraj Hussain, Saber M. Grogg, Matthew W. Kadakia, Madhavi P. Maurer-Gardner, Elizabeth I.
Copyright Year	2016
Abstract	Regulation of gene expression by non-coding RNAs, such as microRNAs (miRNAs), is increasingly being examined in a variety of disciplines. Here we evaluated changes in miRNA expression following metallic nanoparticle (NP) exposure in a mouse neuronal co-culture model. Exposure to manganese (Mn) NPs resulted in oxidative stress, inflammation, and toxicity. Next-generation sequencing (NGS) following an 8 h exposure to Mn NPs (low and high doses) revealed several miRNA candidates that modulate NP induced responses. The lead candidate identified was miR-155, which showed a dose dependent decrease in expression upon Mn exposure. Introduction of a miR-155 mimic into the co-culture to restore miR-155 expression completely abrogated the Mn NP-induced gene and protein expression of inflammatory markers TNF-α and IL-6. Taken together, this study is the first report where global NP-induced miRNA expression changes were used to identify and then modulate negative impacts of metallic NP exposure in a neuronal model. These findings demonstrate that unique miRNA expression profiles provide novel targets for manipulating gene and protein expression, and therefore provide the potential of modifying cellular responses to NP exposure.
Starting Page	1733
Ending Page	1743
Page Count	11
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	6
Journal	Toxicology Research
DOI	10.1039/c6tx00208k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Interleukin 6 Oxidative stress Tumor necrosis factor alpha Gene Mouse Nanoparticle Inflammation Regulation of gene expression Manganese DNA sequencing
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Comparative evaluation of microRNA-155 expression level and its correlation with tumor necrotizing factor α and interleukin 6 in patients with chronic periodontitis.

Comparative evaluation of microRNA-155 expression level and its correlation with tumor necrotizing factor α and interleukin 6 in patients with chronic periodontitis

Association of expression of inflammatory response genes and DNA repair genes in colorectal carcinoma

L-arginine Attenuates Oxidative Stress and Regulates the Inflammatory Actions of Tumor Necrosis Factor and Interleukin-10 in a Rat Model of Pre-eclampsia

Enhancement of lymphokine-activated T killer cell tumor necrosis factor receptor mRNA transcription, tumor necrosis factor receptor membrane expression, and tumor necrosis factor/lymphotoxin release by IL-1 beta, IL-4, and IL-6 in vitro.

Modulation of Anti-Oxidant, Anti-Inflammatory and Metabolism-Controlling Genes Expressions by Ramadan Intermittent Fasting: A Prospective Observational Study

Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor necrosis Factor Alpha (TnF-α) Induced Inflammatory Response in Bovine Cells 1

Tumor necrosis factor alpha and interleukin-6 production (1999).

Myrica salicifolia Hochst. ex A. Rich. suppress acetic acid-induced ulcerative colitis in rats by reducing TNF-alpha and interleukin-6, oxidative stress parameters and improving mucosal protection

Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response

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