NDLI: Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

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Toxicology Research Vol -6

Toxicology Research Vol -5

Toxicology Research Vol - 5 Issue - 6

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Contents list

Developmental windows of susceptibility to inorganic arsenic: a survey of current toxicologic and epidemiologic data

Adenosine diphosphate involvement in THP-1 maturation triggered by the contact allergen 1-fluoro-2,4-dinitrobenzene

Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane

Accumulation of biosynthesized gold nanoparticles and its impact on various organs of Sprague Dawley rats: a systematic study

Microarray analysis and real-time PCR assay developed to find biomarkers for mercury-contaminated soil

MicroRNA-338-5p modulates pulmonary hypertension-like injuries caused by SO₂, NO₂ and PM_2.5 co-exposure through targeting the HIF-1α/Fhl-1 pathway

Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

Signals involved in the effects of bisphenol A (BPA) on proliferation and motility of Leydig cells: a comparative proteomic analysis

Assessment of synergistic thyroid disrupting effects of a mixture of EDCs in ovariectomized rats using factorial analysis and dose addition

Global metabolic changes induced by plant-derived pyrrolizidine alkaloids following a human poisoning outbreak and in a mouse model

Resveratrol and pterostilbene attenuated smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi

Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans

Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner

Cellular uptake, genotoxicity and cytotoxicity of cobalt ferrite magnetic nanoparticles in human breast cells

Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition

⁵⁶Fe irradiation-induced cognitive deficits through oxidative stress in mice

Alteration of mitochondrial phospholipid due to the PLA₂ activation in rat brains under cadmium toxicity

Hepatoprotective activity of viscosine is mediated by attenuation of hepatic macrophages and iNOS expression in CCl₄-intoxicated rats

Cell mechanotactic and cytotoxic response to zinc oxide nanorods depends on substrate stiffness

Effect of dietary protein or calcium supplement on the expression of collagen I and dentine phosphoprotein of rats with dental fluorosis

Metabolomics as a tool to evaluate the toxicity of formulations containing amphotericin B, an antileishmanial drug

Modulation of miRNA-155 alters manganese nanoparticle-induced inflammatory response

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Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Leivas, Fábio Gallas Haas, Sandra Elisa Michels, Luana Roberta Araújo, Flávio Arci Spiazzi, Cristiano Chiapinotto Soares, Melina Bucco Pavin, Natasha Frasson Izaguirry, Aryele Pinto Brum, Daniela dos Santos Santos, Francielli Weber
Copyright Year	2016
Abstract	Quinine is an antimalarial drug; however, its use is limited by its narrow therapeutic index and elevated side effects. The nanosystems are promising delivery vehicles of antimalarial drugs, enhancing their therapeutic potential. This study aimed to compare the toxicity of quinine and quinine loaded nanocapsules (Q-NC) on the reproductive system of male and female rats. The animals received quinine or Q-NC orally at the same dose of 25 mg kg−1 for 7 days (real period of quinine therapy in humans). 24 hours after the last administration, the rats were euthanized and the ovarian and testicular tissues were removed for histological and biochemical analyses. The groups treated with quinine presented ovarian and testicular damage, evidenced by the increase of reactive species and malondialdehyde levels, the decrease of 17β-hydroxysteroid dehydrogenase activity and alterations on total antioxidant capacity. The females presented a decrease of follicular viability and the males presented a decrease of spermatozoa membrane integrity, as well as moderated histological alterations on testis after the exposure to quinine. After the treatment with Q-NC, the males presented decreased reactive species levels and total antioxidant capacity at control levels, as well as spermatozoa with 100% of membrane integrity. The females treated with Q-NC presented reactive species levels, total antioxidant capacity, 17β-hydroxysteroid dehydrogenase activity and follicular viability at control levels, and decreased malondialdehyde levels when compared to quinine, but not at control levels. This study demonstrated that loading polymeric nanocapsules with quinine decreased the deleterious effects induced by quinine on ovaries and partially on testicles.
Starting Page	1561
Ending Page	1572
Page Count	12
File Format	HTM / HTML PDF
ISSN	2045452X
Volume Number	5
Issue Number	6
Journal	Toxicology Research
DOI	10.1039/c6tx00203j
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Spermatozoon Ovary The Animals Animal euthanasia 17Beta Hydroxysteroid dehydrogenase Antioxidant Testicle Quinine Antimalarial medication Nanotechnology Malondialdehyde
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Toxicology

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Lead aggravates the diabetic-induced reproductive toxicity in male Wistar rats

17beta-hydroxysteroid dehydrogenase 3 deficiency in a male

Subchronic cyanide toxicity on male reproductive system of albino rat

Testicular and epididymal toxicity induced by benzo(a)pyrene, alcohol, and their combination in Wistar rats

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17beta-hydroxysteroid dehydrogenase 3 deficiency in a male pseudohermaphrodite

Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine

Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats.

Role of hydroxysteroid (17beta) dehydrogenase type 1 in reproductive tissues and hormone-dependent diseases

Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats

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Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats