NDLI: Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats

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Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats

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Food & Function Vol - 7 Issue - 2

Food & Function Vol -6

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Food & Function Vol -4

Food & Function Vol -3

Food & Function Vol -2

Food & Function Vol -1

Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats

Content Provider	Royal Society of Chemistry (RSC)
Author	Reddy, P. Yadagiri Jakhotia, Sneha Reddy, G. Bhanuprakash Raghu, G. Kumar, P. Anil
Copyright Year	2016
Abstract	The formation of advanced glycation end products (AGEs) is a characteristic feature of diabetic tissues and accumulation of these products has been implicated in the pathogenesis of micro- and macrovascular complications of diabetes including diabetic nephropathy (DN). Compelling evidence suggests that AGEs mediate progressive alteration in the renal architecture and loss of renal function whereas inhibitors of AGEs prevent the progression of experimental DN. We have investigated the potential of ellagic acid (EA), a polyphenol present abundantly in fruits and vegetables, to prevent in vivo accumulation of AGE and to ameliorate renal changes in diabetic rats. Streptozotocin-induced diabetic rats were fed with either 0.2% or 2% of EA in the diet for 12 weeks. Dietary supplementation of EA to diabetic rats prevented the glycation mediated RBC-IgG-cross-links and HbA1c accumulation. EA inhibited the accumulation of N-carboxymethyl lysine (CML), a predominant AGE in the diabetic kidney. Further, EA also prevented the AGE-mediated loss of expression of podocyte slit diaphragm proteins: nephrin and podocin. By inhibiting CML formation, EA improved renal function in rats as evidenced by urinary albumin and creatinine levels. In conclusion, EA inhibited AGE accumulation in the diabetic rat kidney and ameliorated AGE-mediated pathogenesis of DN.
Starting Page	1574
Ending Page	1583
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	7
Issue Number	3
Journal	Food & Function
DOI	10.1039/c5fo01372k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	EA CML Glycation Diabetic nephropathy Acid Polyphenol Glycated hemoglobin Lysine Kidney Podocyte Thoracic diaphragm Nephrin Podocin Serum albumin Creatinine
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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FK506 reduces albuminuria through improving podocyte nephrin and podocin expression in diabetic rats

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Ellagic acid inhibits non-enzymatic glycation and prevents proteinuria in diabetic rats

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