NDLI: hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer

Content Provider	PubMed Central
Author	Crociani, Olivia Francesca, Zanieri Serena, Pillozzi Elena, Lastraioli Stefanini, Matteo Fiore, Antonella Fortunato, Angelo D'amico, Massimo Marika, Masselli Lorenzo, Emanuele De Luca, Gasparoli Chiu, Martina Ovidio, Bussolati Andrea, Becchetti Arcangeli, Annarosa
Copyright Year	2013
Abstract	Angiogenesis is a potential target for cancer therapy. We identified a novel signaling pathway that sustains angiogenesis and progression in colorectal cancer (CRC). This pathway is triggered by β1 integrin-mediated adhesion and leads to VEGF-A secretion. The effect is modulated by the human ether-à-go-go related gene 1 (hERG1) K+ channel. hERG1 recruits and activates PI3K and Akt. This in turn increases the Hypoxia Inducible Factor (HIF)-dependent transcription of VEGF-A and other tumour progression genes. This signaling pathway has novel features in that the integrin- and hERG1-dependent activation of HIF (i) is triggered in normoxia, especially after CRC cells have experienced a hypoxic stage, (ii) involves NF-kB and (iii) is counteracted by an active p53. Blocking hERG1 switches this pathway off also in vivo, by inhibiting cell growth, angiogenesis and metastatic spread. This suggests that non-cardiotoxic anti-hERG1 drugs might be a fruitful therapeutic strategy to prevent the failure of anti-VEGF therapy.
Related Links	http://dx.doi.org/10.1038/srep03308
Starting Page	3308
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2013-11-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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