NDLI: SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers

Content Provider	PubMed Central
Author	Matsuura, Shun Kahyo, Tomoaki Shinmura, Kazuya Moriya, Iwaizumi Yamada, Hidetaka Funai, Kazuhito Kobayashi, Jun Tanahashi, Masayuki Niwa, Hiroshi Ogawa, Hiroshi Takahashi, Takashi Inui, Naoki Suda, Takafumi Chida, Kingo Watanabe, Yoshinori Sugimura, Haruhiko
Copyright Year	2013
Abstract	Mitosis is the most conspicuous cell cycle phase and Shugoshin-like 1 (SGOL1) is a key protein in protecting sister chromatids from precocious separation during mitosis. We studied the role of SGOL1 and its splice variants in non-small cell lung cancer (NSCLC) using 82 frozen NSCLC tissue samples. SGOL1-B expression was prevalent in smokers, in cases with a wild-type (WT) EGFR status, and in cases with the focal copy number amplification of genes that are known to be important for defining the biological behaviors of NSCLC. The overexpression of SGOL1-B1 in an NSCLC cell line induced aberrant chromosome missegregation, precociously separated chromatids, and delayed mitotic progression. A higher level of SGOL1-B mRNA was related to taxane resistance, while the forced downregulation of SGOL1-B increased the sensitivity to taxane. These results suggest that the expression of SGOL1-B causes abnormal mitosis and taxane resistance in NSCLC cells.
Related Links	http://dx.doi.org/10.1038/srep03012
Starting Page	3012
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2013-10-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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