NDLI: PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer

Content Provider	PubMed Central
Author	Sato, Teruyuki Kaneda, Atsushi Tsuji, Shingo Isagawa, Takayuki Yamamoto, Shogo Fujita, Takanori Yamanaka, Ryota Tanaka, Yukiko Nukiwa, Toshihiro Marquez, Victor E. Ishikawa, Yuichi Ichinose, Masakazu Hiroyuki, Aburatani
Copyright Year	2013
Abstract	Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC. ChIP-seq for H3K27me3 suggested that genes with H3K27me3(+) in SCLC were extended not only to PRC2-target genes in ES cells but also to other target genes such as cellular adhesion-related genes. These H3K27me3(+) genes in SCLC were repressed significantly, and introduction of the most repressed gene JUB into SCLC cell line lead to growth inhibition. Shorter overall survival of clinical SCLC cases correlated to repression of JUB alone, or a set of four genes including H3K27me3(+) genes. Treatment with EZH2 inhibitors, DZNep and GSK126, resulted in growth repression of SCLC cell lines. High PRC2 expression was suggested to contribute to gene repression in SCLC, and may play a role in genesis of SCLC.
Related Links	http://dx.doi.org/10.1038/srep01911
Starting Page	1911
File Format	PDF
ISSN	20452322
e-ISSN	20452322
Journal	Scientific Reports
Volume Number	3
Language	English
Publisher	Nature Publishing Group
Publisher Date	2013-05-29
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Science and technology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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