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| Content Provider | PubMed Central |
|---|---|
| Author | Wang, Ling Wang, Yu Liang, Yong Li, Jia Liu, Yuchen Zhang, Jie Zhang, Aiqian Fu, Jianjie Jiang, Guibin |
| Copyright Year | 2013 |
| Abstract | Lipid droplets (LDs), which are important storage structures for neutral lipids and organelles of diverse functions, participate in various cellular activities. In this study, BALB/c mice, fed a regular or a high-fat diet, were exposed to the synthetic perfluorinated compound, perfluorooctanoic acid (PFOA). PFOA-exposed mice had altered serum lipid and lipoprotein levels, and hydropic degeneration or ballooning degeneration of hepatocytes. Moreover, we report for the first time that LDs accumulate in hepatic nuclei after PFOA exposure. As PFOA resembles fatty acids (FA) in its structure, this chemical may interfere with the transportation and metabolism of FA as well as LDs in the cell. This abnormal localization of LDs in the nucleus may be related to the cause of PFOA toxicity. |
| Related Links | http://dx.doi.org/10.1038/srep02174 |
| Starting Page | 2174 |
| File Format | |
| ISSN | 20452322 |
| e-ISSN | 20452322 |
| Journal | Scientific Reports |
| Volume Number | 3 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2013-07-12 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Science and technology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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