NDLI: The Component Analysis of Propofol and Etomidate Mixture and Its Clinical Efficacy

Content Provider	IEEE Xplore Digital Library
Author	Yong Liao Yan You Xuejun Zhou Yang Guo Zhipeng Tang Qin Wang Daolin Jian
Copyright Year	2015
Description	Author affiliation: Dept. of Pharmacy, Renhe Hosp. of Three Gorges Univ., Yichang, China (Yong Liao; Yan You; Xuejun Zhou; Yang Guo; Zhipeng Tang; Qin Wang; Daolin Jian)
Abstract	At present, medication safety is the key event in hospital. This paper discusses the pharmacy stability of propofol and etomidate mixture and its clinical efficacy in combination. In order to solve the problem efficiently, we adopt a high performance liquid chromatography(HPLC)and a nuclear magnetic resonance spectroscopy(NMR) to determinate the stability of propofol and etomidate mixture fristly. Then 120 patients of early pregnancy undergoing abortion surgeries were randomly assigned to propofol group(P group), etomidate group(E group) and propofol + etomidate group(EP group). Patients in P group were induced with 1% propofol 15ml. In E group, Patients were induced with 0.2% etomidate 15ml. In EP group, induction was performed with 1% propofol 10ml and 0.2% etomidate 5ml. To compare the results of hemodynamics, injection pain, myoclonus and recovery time among groups. As a results, the comparision of HPLC and H1-NMR showed nice chemical stability of samples. EP group has obvious advantages.
Sponsorship	Hunan Inst. Ind.
Starting Page	1152
Ending Page	1155
File Size	808406
Page Count	4
File Format	PDF
e-ISBN	9781467371438
DOI	10.1109/ICMTMA.2015.280
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-06-13
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Pain Clinical efficacy in combination Anesthesia Stability analysis Nuclear magnetic resonance Propofol Thermal stability Chemicals Etomidate
Content Type	Text
Resource Type	Article

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