NDLI: Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

Content Provider	IEEE Xplore Digital Library
Author	Liu Hongying Fang Juan Li Qingli Zhang Jingfa
Copyright Year	2015
Description	Author affiliation: Dept. of Regenerative Med., Tongji Eye Inst., Shanghai, China (Zhang Jingfa) \|\| Shanghai Key Lab. of Multidimensional Inf. Process., East China Normal Univ., Shanghai, China (Liu Hongying; Fang Juan; Li Qingli)
Abstract	AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyper spectral imaging system (MHIS). Molecular hyper spectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.
Sponsorship	Hunan Inst. Ind.
Starting Page	411
Ending Page	414
File Size	410536
Page Count	4
File Format	PDF
e-ISBN	9781467371438
DOI	10.1109/ICMTMA.2015.105
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-06-13
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Diabetic retinopathy Biomedical optical imaging Retinopathy Rats Retina Optical imaging AAV2-EPO ONL Spectral Angle MHSI qualitative analysis Diabetes Hyperspectral imaging
Content Type	Text
Resource Type	Article

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