NDLI: Chemical Informatic Investigation of Anticancer Secondary Metabolites from Spina Gleditsiae Using HPLC and NMR-based Techniques

Content Provider	IEEE Xplore Digital Library
Author	Jiayu Gao Ranran Cao Weiping Yin
Copyright Year	2015
Description	Author affiliation: Sch. of Chem. Eng. & Pharm., Henan Univ. of Sci. & Technol., Luoyang, China (Jiayu Gao; Ranran Cao; Weiping Yin)
Abstract	Spina Gleditsiae is the herbal medicine traditionally used in Chinese Medicine for the treatment of human cancers. Though significant progress has been made toward our understanding of the antitumour mechanisms of Spina Gleditsiae, its anticancer chemical information remains unclear. In this study, we used computer-based chromatographic and spectral techniques to isolate and identify nine compounds including fustin(1), (+) trans-2R, 3R-3', 4', 5, 7-tetrahydroxyflavanonol (2), 8-C-glucopyranosyl-3, 4', 7-trihydroxyflavone (3), dihydrokaempferol (4), 5-methoxy-3', 4', 7'-trihydroxydihydroflavonol (5), 5, 3', 4', trimethoxy-7-hydroxydihydroflavonol (6), betulin (7), ß-sitosterol (8) and 2ß-carboxyl, 3ß-hydroxyl-norlupA (1)-20(29)-en-28-oic acid (9) from Spina Gleditsiae. Moreover, their anticancer effects were firstly confirmed on hepatoblastoma HepG2, oesophageal carcinoma EC109 and lung adenocarcinoma A549 cell lines in vitro. Our results provide a theoretical basis for the potential therapeutic use of Spina Gleditsiae in the treatment of malignancies.
Sponsorship	Hunan Inst. Ind.
Starting Page	267
Ending Page	270
File Size	321511
Page Count	4
File Format	PDF
e-ISBN	9781467371438
DOI	10.1109/ICMTMA.2015.71
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-06-13
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	triterpenoid Ethanol Lungs Liver Spina Gleditsiae flavonoid Compounds In vitro MTT assay Petroleum anticancer Cancer
Content Type	Text
Resource Type	Article

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