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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Kwan, J.Y.Y. Kwan, B.Y.M. Hon Keung Kwan |
| Copyright Year | 2010 |
| Description | Author affiliation: Faculty of Medicine, University of Ottawa, Ontario, Canada K1H 8MS (Kwan, B.Y.M.) || Department of Electrical & Computer Engineering, University of Windsor, Ontario, Canada N9B 3P4 (Hon Keung Kwan) || Department of Laboratory Medicine & Pathobiology, University of Toronto, Ontario, Canada M5S 1A8 (Kwan, J.Y.Y.) |
| Abstract | Analysis of DNA sequences requires conversion of a base sequence to a numerical sequence. The choice of the numerical mapping of a DNA sequence affects how well its biological properties can be reflected in the numerical domain for the detection of regions of interest. This paper presents twelve one-sequence numerical representation methods and a discrete Fourier transform (DFT) based approach to extract the period-3 value of DNA sequences for classifying exon and intron sequences. Simulations are carried out using short sequences of the human genome; the results obtained indicate that the threshold value determined and consequently the classification performance is a function of the adopted numerical representation method and its window length. |
| Starting Page | 876 |
| Ending Page | 877 |
| File Size | 350671 |
| Page Count | 2 |
| File Format | |
| ISBN | 9781424483037 |
| e-ISBN | 9781424483044 |
| DOI | 10.1109/BIBMW.2010.5703954 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Training Discrete Fourier transforms DNA sequences Genomics DNA numerical representation Signal processing spectral analysis exon and intron classificaton Computational efficiency Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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