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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Xiaona Wei Yuzong Chen |
| Copyright Year | 2010 |
| Description | Author affiliation: Department of Pharmacy Department of Pharmacy and Center of Computational Science and Engineering, National University of Singapore, Singapore 117576 (Yuzong Chen) || Singapore-MIT Alliance, National University of Singapore, Singapore 117576 (Xiaona Wei) |
| Abstract | Endothelial permeability is involved in a number of diseases. Three key mediators, thrombin, histamine, and VEGF induce endothelial permeability partly via activating myosin light chain (MLC) via specific pathways. Quantitative analysis of the relevant signaling events are important for facilitating the understanding of the molecular mechanism and signaling dynamics leading to endothelial permeability. Ordinary differential equation (ODE) based mathematical models have been developed and used for simulating MLC activation by the thrombin-mediated pathway and by $Ca^{2+}$ and MLCK. Additional mathematical models need to be developed to facilitate more comprehensive analysis of the signaling events and regulations in endothelial permeability. By extending the published simulation models, we reproduced simulation model of the thrombin-mediated pathway and developed new simulation models of the histamine-mediated and VEGF-mediated pathways, which were validated by available experimental and simulation results. |
| Starting Page | 847 |
| Ending Page | 848 |
| File Size | 409164 |
| Page Count | 2 |
| File Format | |
| ISBN | 9781424483037 |
| e-ISBN | 9781424483044 |
| DOI | 10.1109/BIBMW.2010.5703939 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Pathway simulation Histamine Computational modeling Biological system modeling Calcium Simulation VEGF Thrombin Permeability Mathematical model Endothelial hyperpermeability Diseases |
| Content Type | Text |
| Resource Type | Article |
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