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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Min-Yu Huang Weber, G.H. Xiao-Yong Li Biggin, M.D. Hamann, B. |
| Copyright Year | 2010 |
| Description | Author affiliation: Visualization Group, Lawrence Berkeley National Laboratory (LBNL), One Cyclotron Road, CA 94720, USA (Weber, G.H.) || Institute for Data Analysis and Visualization (IDAV), Department of Computer Science, University of California, Davis, One Shields Avenue, 95616, USA (Min-Yu Huang; Hamann, B.) || Genomics Divisions, Lawrence Berkeley National Laboratory (LBNL), One Cyclotron Road, CA 94720, USA (Xiao-Yong Li; Biggin, M.D.) |
| Abstract | Most analyses of ChIP-chip in vivo DNA binding have focused on qualitative descriptions of whether genomic regions are bound or not. There is increasing evidence, however, that factors bind in a highly overlapping manner to the same genomic regions and that it is quantitative differences in occupancy on these commonly bound regions that are the critical determinants of the different biological specificity of factors. As a result, it is critical to have a tool to facilitate the quantitative visualization of differences between transcription factors and the genomic regions they bind to understand each factor's unique roles in the network. We have developed a framework which combines several visualizations via brushing-and-linking to allow the user to interactively analyze and explore in vivo DNA binding data of multiple transcription factors. We describe these visualization types and also provide a discussion of biological examples in this paper. |
| Starting Page | 195 |
| Ending Page | 200 |
| File Size | 676756 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781424483037 |
| e-ISBN | 9781424483044 |
| DOI | 10.1109/BIBMW.2010.5703798 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Visualization Correlation Image color analysis Data visualization Genomics Browsers ChIP-chip Analysis Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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