Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Peipei Li Ho Sun Shon Keun Ho Ryu Gouchol Pok |
| Copyright Year | 2010 |
| Description | Author affiliation: Database/Bioinformatics Lab, Chungbuk National University, Korea (Peipei Li; Ho Sun Shon; Keun Ho Ryu) || Department of Computer Science, Yanbian University of Science and Technology, Yanji, China (Gouchol Pok) |
| Abstract | Protein amino acid solvent exposure plays a crucial role in understanding, analyzing and predicting protein structure and function. In this paper, we propose a novel three-dimensional measure of solvent exposure named Eighth-Sphere Exposure based on three-dimensional protein structures. This measure supposes a sphere with a radius of 13Å around a Cα atom, and subdivides its microenvironment into eight quadrants according to a space rectangular coordinate system, constructed by the four backbone amino acid atoms Cα, Cβ, C and N. The number of the neighboring Cα atoms is calculated as the Eighth-Sphere Exposure values. Our analysis is further based on 689 randomly-selected protein chains from a representative and nonredundant data set obtained from PDB-REPRDB database, and histograms are obtained. The performances are analyzed and compared with other solvent exposure measures such as Contact Number and Half-Sphere Exposure. As the eight histograms of Half-Sphere Exposure show very different distributions compared to each other, it indicates that the described division of a residue's spherical neighborhood indeed captures regions with different properties. Our method provides a different view of solvent exposure, and it supplies more characteristic structure information than the Contact Number and Half-Sphere Exposure methods. It is believed that Eighth-Sphere Exposure can be useful in protein structure analysis, prediction, and other areas. |
| Starting Page | 41 |
| Ending Page | 46 |
| File Size | 455838 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781424483037 |
| e-ISBN | 9781424483044 |
| DOI | 10.1109/BIBMW.2010.5703770 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins Atomic measurements Solvents Histograms Protein engineering Eighth-Sphere Exposure Protein amino acid solvent exposure Three-dimensional protein structures Amino acids Size measurement Protein structure |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|