NDLI: Recent research and emerging challenges in design and optimization for digital microfluidic biochips

Content Provider	IEEE Xplore Digital Library
Author	Tsung-Wei Huang Yan-You Lin Jia-Wen Chang Tsung-Yi Ho
Copyright Year	2011
Description	Author affiliation: Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA (Yan-You Lin) \|\| Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan (Tsung-Wei Huang; Jia-Wen Chang; Tsung-Yi Ho) Advances in droplet-based digital microfluidic biochips (DMFBs) have led to the emergence of biochips for automating laboratory procedures in biochemistry and molecular biology. These devices enable the precise control of microliter of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. To meet the challenges of increasing design complexity, computer-aided-design (CAD) tools have been involved to build DMFBs efficiently. This paper provides an overview of DMFBs and describes emerging CAD tools for the automated synthesis and optimization of DMFB designs, from fluidic-level synthesis to chip-level design. Design automations are expected to relieve the design burden of manual optimization of bioassays, time-consuming chip designs, and costly testing and maintenance procedures. With the assistance of CAD tools, users can concentrate on the development and abstraction of nanoscale bioassays while leaving chip optimization and implementation details to CAD tools.
Starting Page	12
Ending Page	17
File Size	1668688
Page Count	6
File Format	PDF
ISBN	9781457716164
ISSN	21641706
e-ISBN	9781457716171
e-ISBN	9781457716157
DOI	10.1109/SOCC.2011.6085143
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-09-26
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Wires Performance evaluation
Content Type	Text
Resource Type	Article

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