NDLI: Recent research and emerging challenges in the System-Level Design of digital microfluidic biochips

Content Provider	IEEE Xplore Digital Library
Author	Pop, P. Maftei, E. Madsen, J.
Copyright Year	2011
Description	Author affiliation: DTU Informatics, Technical University of Denmark, Kongens Lyngby, Denmark (Pop, P.; Maftei, E.; Madsen, J.)
Abstract	Microfluidic biochips are replacing the conventional biochemical analyzers, and are able to integrate on-chip all the basic functions for biochemical analysis. The “digital” biochips are manipulating liquids not as a continuous flow, but as discrete droplets on a two-dimensional array of electrodes. Basic microfluidic operations, such as mixing and dilution, are performed on the array, by routing the corresponding droplets on a series of electrodes. The challenges facing biochips are similar to those faced by microelectronics some decades ago. Computer-Aided Design tools for microfluidics are in their infancy, and designers are currently using manual, bottom-up design approaches to implement such biochips. Considering their architecture and the design tasks that have to be performed, the design of digital biochips has similarities to the high-level synthesis of integrated circuits. Motivated by this similarity, a few researchers have recently started to propose approaches for the top-down design of biochips. So far, they have assumed that operations are executing on virtual modules of rectangular shape, formed by grouping adjacent electrodes, and which have a fixed placement on the array. However, operations can actually execute by routing the droplets on any sequence of electrodes on the biochip. In this paper, we outline the original module-based synthesis problem, and then we present recent work which eliminates the concept of virtual modules and allows droplets to move on the chip on any route during operation execution. We discuss the advantages of such an approach, and identify the challenges and opportunities of system-level design of digital microfluidic biochips.
Starting Page	6
Ending Page	11
File Size	1125505
Page Count	6
File Format	PDF
ISBN	9781457716164
ISSN	21641706
e-ISBN	9781457716171
e-ISBN	9781457716157
DOI	10.1109/SOCC.2011.6085142
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-09-26
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Bismuth Mixers Adaptive arrays Plasmas
Content Type	Text
Resource Type	Article

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