NDLI: Performance evaluation of the low-cost high-sensitivity rodent research PET (RRPET) camera using Monte Carlo simulations

Content Provider	IEEE Xplore Digital Library
Author	Yuxuan Zhang Wai-Hoi Wong Baghaei, H. Soonseok Kim Hongdi Li Jiguo Liu Shitao Liu Ramirez, R. Yu Wang Shuping Xie
Copyright Year	2005
Description	Author affiliation: Texas Univ., Houston, TX (Yuxuan Zhang; Wai-Hoi Wong; Baghaei, H.; Soonseok Kim; Hongdi Li; Jiguo Liu; Shitao Liu; Ramirez, R.; Yu Wang; Shuping Xie)
Abstract	BGO pentagonal blocks are used to build a solid detector cylinder for a rodent research PET (RRPET). With the PMT-quadrant-sharing design, this camera is low-cost and has higher sensitivity than commercial animal PET. The performance parameters of RRPET are obtained using Monte Carlo simulations by GATE, a newly developed toolkit based on GEANT4 for PET/SPECT. Two models of the RRPET system, one 30-sided-polygon geometry model and one 10-sided-polygon electronics model with different time-response constants, are used in the simulations to get the accurate results for both geometry-related and time-related parameters, including the sensitivity, count rate and resolution. Several types of sources are simulated, including a point source, a linear source, and several uniform sources simulating the mouse and the rat. The simulations give the noise equivalent count rate (NECR) curves with the maximum NECR of 2.2 Mcps @ 1.5 mCi for point source, 750 kcps @ 1.5 mCi for mouse-like source and 290 kcps @ 1.0 mCi for rat-like source; the sensitivity is 10.3%; the spatial resolution at the center of the field of view (FOV) is 1.6 mm for an $^{18}F$ source inside water phantom; the radial and tangential resolution at the edge of the FOV (10 cm) is 3.2 mm and 2.2 mm, respectively. Preliminary experiments showed a sensitivity of 8.4% to 10.2% (depending on electronics) and a resolution of 1.8 mm with a $^{22}Na$ source. By comparing the simulation and experiment results, the resolution degradation from the mechanical misalignment and the block-decoding blurring is found to be 1.1 mm
Starting Page	2514
Ending Page	2518
File Size	759108
Page Count	5
File Format	PDF
ISBN	0780392213
ISSN	10957863
DOI	10.1109/NSSMIC.2005.1596851
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-10-23
Publisher Place	Puerto Rico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Rodents Positron emission tomography Cameras Solid modeling Spatial resolution Detectors Animals Geometry Mice Water resources
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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