NDLI: GATE Monte Carlo Simulation of a High-Sensitivity and High-Resolution LSO-Based Small Animal PET Camera

Content Provider	IEEE Xplore Digital Library
Author	Baghaei, H. Yuxuan Zhang Hongdi Li Yu Wang Soonseok Kim Ramirez, R.A. Jiguo Liu Shitao Liu Wai-Hoi Wong
Copyright Year	1963
Abstract	In this paper, we describe a Monte Carlo simulation of the performance of a high-sensitivity and high-resolution small animal positron emission tomography (PET) scanner with a large axial fleld-of-view (AFOV). The simulated camera is based on the photomultiplier-quadrant-sharing (PQS) concept and composed of 180 blocks of 14 times 14 lutetium oxyorthosilicate (LSO) crystals each measuring 1.16 mm transaxially, 1.27 mm transaxially, and 9.4 mm radially. The camera has 84 detector rings with an 11.6 cm AFOV and a ring diameter of 16.6 cm. For the simulation, we used the Geant4 Application for Tomographic Emission (GATE) simulation package. We validated GATE by comparing its predictions for spatial resolution, absolute sensitivity, and count rate with measured data obtained using an existing bismuth germanate (BGO) based dedicated animal PET scanner that had a similar AFOV and ring diameter and was based on the PQS technique. Simulated and experimental images of the Data Spectrum Micro Deluxe phantom were also compared. The simulation data suggested that new LSO-based scanner could have reconstructed radial (tangential) spatial resolutions of 1.14 mm (1.14 mm), 1.31 mm (1.32 mm), 1.54 mm (1.52 mm), 2.01 mm (1.8 mm), and 2.4 mm (2.1 mm) at the center and 1 cm, 2 cm, 3 cm, and 4 cm off center, respectively. The simulation data also suggested that 1.2-mm hot rods in the Micro Deluxe phantom will be distinguishable. Simulation predicted an absolute sensitivity of about 7.3% for a point source at the center of the camera assuming an energy window of 300 keV to 750 keV, a coincidence time window of 8 ns, and a system dead time of 60 ns.
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	1568
Ending Page	1573
Page Count	6
File Size	641681
File Format	PDF
ISSN	00189499
Volume Number	54
Issue Number	5
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Animals Positron emission tomography Cameras Spatial resolution Imaging phantoms Crystals Detectors Packaging Bismuth Image reconstruction positron emission tomography (PET) GATE Geant4 Monte Carlo simulations
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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