NDLI: Monte-Carlo modeling of the microPET R4 small animal PET scanner for coincidence-mode emission and singles-mode transmission data acquisition

Content Provider	IEEE Xplore Digital Library
Author	Vandervoort, E. Camborde, M.-L. Jan, S. Sossi, V.
Copyright Year	2005
Description	Author affiliation: Dept. of Phys. & Astron., British Columbia Univ., Vancouver, BC (Vandervoort, E.)
Abstract	We present an extension of the simulation tool GATE for singles-mode transmission tomography and its validation using experimental data from the microPET R4 scanner. Before using GATE to model transmission data, we first validated our simulated PET scanner by comparing experimental and simulated resolution and scatter fractions (SFs) for coincidence-mode sinogram data. Two levels of complexity were simulated for emission sources. The first level neglected beta+ interactions and only modeled the emission of perfectly collinear annihilation gamma-rays. For these data simulated FWHMs were on average 0.9 mm narrower and the simulated SFs were 9% lower than experimental values. The second type of simulation included beta+ interactions. When compared to experimental values, the simulated FWHMs for these data differed by less than 0.4 mm on average and SFs agreed to within 2%. For singles-mode transmission data, we have compared simulated and experimental data for three different sized water phantoms using $^{57}Co$ (ap124 keV gamma-emitter) and 68 Ge $(beta^{+}-emitter)$ transmission sources. We have currently only modeled $gamma^{+}$ interactions for the 68 Ge source. The average difference between experimental and simulated SFs were 4.6% and 6.5% for the $^{57}Co$ and 68 Ge sources, respectively. The simulated attenuation correction factors (ACFs) and effective attenuation coefficients were also in better agreement with experimental values for $^{57}Co$ than for $^{68}Ge$ data. Our results may be improved by including the effects of detector dead-time. Although some additional development is still planned, this new transmission tomography tool has already provided insight into the effects which degrade the accuracy of the ACFs obtained from singles-mode scans and may soon become useful by providing realistic simulated transmission data. These data could help improve the design and performance of PET transmission hardware and aide in the development of reconstruction and correction techniques
Starting Page	2449
Ending Page	2453
File Size	308608
Page Count	5
File Format	PDF
ISBN	0780392213
ISSN	10957863
DOI	10.1109/NSSMIC.2005.1596837
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-10-23
Publisher Place	Puerto Rico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Animals Positron emission tomography Data acquisition Attenuation Scattering Water resources Imaging phantoms Detectors Degradation Hardware
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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