NDLI: Magneto-nanosensor for sensitive detection of ovarian cancer antibody biomarker anti-Selenium-Binding Protein 1

Content Provider	IEEE Xplore Digital Library
Author	Gani, A. Edassery, S. Xu, L. Lee, J. Luborsky, J. Wang, S.X.
Copyright Year	2015
Description	Author affiliation: Stanford Univ., Stanford, CA, USA (Gani, A.; Xu, L.; Lee, J.; Wang, S.X.) \|\| Rush Univ. Med. Center, Chicago, IL, USA (Edassery, S.; Luborsky, J.)
Abstract	Autoantibody biomarker relatively recently gains a lot of research interest for early detection of cancer. Cancer autoantibody is an antibody produced by the host's immune system in response to tumor antigen. It is produced at a much earlier disease stage before other biomarkers can be observed, circulates in the serum for a relatively long period of time, and is present at higher concentrations than antigen biomarkers. In addition to identifying the early antibody biomarker, early detection of cancer needs to be complemented by the availability of ultrasensitive and reliable detection platform. Magneto-Nanosensor is a robust biomolecular diagnostics platform that has been shown to have superior sensitivity and dynamic range compared to the current gold standard ELISA (Enzyme-linked Immunosorbent Assay). One potential antibody biomarker for the early detection of ovarian cancer is anti-Selenium-Binding Protein 1 (anti-SBP1, also known as anti-SELENBP1). Studies showed that concentration levels of SBP1 are associated with cancer progression. This submission reports highly-sensitive and reliable detection of anti-SBP1 using magnetic immunoassay technique on Magneto-Nanosensor platform. The high sensitivity of our detection platform combined with the early antibody biomarker can serve as a powerful diagnostic tool for enabling early detection of ovarian cancer.
Starting Page	1
Ending Page	1
File Size	245524
Page Count	1
File Format	PDF
e-ISBN	9781479973224
DOI	10.1109/INTMAG.2015.7157494
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-05-11
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic sensors Cancer Immune system Sensitivity Standards Dynamic range
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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