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Selenium-Binding Protein 1 (SBP1) autoantibodies in ovarian disorders and ovarian cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yu-Rice, Yi Edassery, Seby Louis Urban, Nicole D. Hellstrom, Ingegerd Hellstrom, Karl Erik Deng, Youping Luborsky, Judith |
| Copyright Year | 2017 |
| Abstract | Infertility is a risk factor for ovarian cancer (OvCa). The goal was to determine if antibodies to selenium-binding protein 1 (SBP1), an autoantibody we identified in patients with premature ovarian failure (POF), occurs in both infertility and OvCa patients, and thus could be associated with preneoplasia. Anti-SBP1 was measured by immunoassay against recombinant SBP1, in sera from OvCa (n = 41), infertility (n = 92) and control (n = 87) patients. Infertility causes were POF, unexplained, irregular ovulation or endometriosis. The percent of anti-SBP1-positive sera was higher in POF (P = 0.02), irregular ovulation (P = 0.001), unexplained causes (P = 0.02), late (III-IV)-stage OvCa (P = 0.02) but was not significant in endometriosis, benign ovarian tumors/cysts, early stage (I-II) OvCa or uterine cancer compared to healthy controls. Anti-SBP1 was significantly higher in women with serous (P = 0.04) but not non-serous (P = 0.33) OvCa compared to controls. Also, we determined if anti-SBP1 was associated with CA125 or anti-TP53, markers often studied in OvCa. Anti-TP53 and CA125 were measured by established immunoassays. The ability of anti-SBP1 alone to discriminate infertility or OvCa from controls or when combined with anti-TP53 and CA125, to identify OvCa was evaluated by comparing the area under the curve (AUC) in ROC analysis. Anti-SBP1 alone discriminated infertility (AUC = 0.7; P = 0.001) or OvCa (AUC = 0.67; P = 0.03) from controls. The sensitivity and specificity of OvCa identification was increased by combining CA125, anti-TP53 and anti-SBP1 (AUC = 0.96). Therefore, anti-SBP1 occurs in infertile women with POF, ovulatory disturbances or unexplained infertility and in serous OvCa. This suggests an autoimmune process is associated with the development of serous OvCa. |
| Starting Page | 277 |
| Ending Page | 284 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1530/REP-16-0265 |
| PubMed reference number | 27965399 |
| Journal | Medline |
| Volume Number | 153 |
| Issue Number | 3 |
| Alternate Webpage(s) | https://www.promeddx.com/assets/197_Selenium-Binding-Protein-1-SBP1-autoantibodies-in-ovarian-disorders-and-ovarian-cancer-2Full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1530/REP-16-0265 |
| Journal | Reproduction |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
