NDLI: Quantitative measurement of creatine content in skeletal muscle using /sup 1/H-MRS

Content Provider	IEEE Xplore Digital Library
Author	Saotome, T. Sekino, M. Eto, F. Ueno, S.
Copyright Year	2005
Description	Author affiliation: Dept. of Biomed. Eng., Tokyo Univ., Japan (Saotome, T.; Sekino, M.)
Abstract	Magnetic resonance spectroscopy (MRS) is used for non-invasively investigating metabolism and concentration of biomolecules in skeletal muscles and other tissues. MRS has a potential to become a tool for clinical diagnosis and for predicting disease prognosis. In this study, the /sup 1/H spectra of skeletal muscles with and without atrophy were obtained and a quantitative evaluation of the content of creatine in the muscles was performed. The left sciatic nerves of nine week old rats were transected and at 2 and 4 weeks after the surgery, /sup 1/H spectra of the muscles were obtained. Spectra of 11 and 13 weeks old normal rats were also obtained for controls. Water spectra were acquired from a 2/spl times/2/spl times/2 mm/sup 3/ voxel located on the left gastrocnemius muscle. The signal intensities and the relaxation times of water and creatine were then estimated. Results show that the prolongation of the T/sub 1/ relaxation times of water in the denervated muscle is attributable to a decrease in the muscle water content and an increase in the extracellular fluid space. Creatine is involved with the reaction for producing adenosine triphosphate, the essential energy source for muscular contraction. The quantification of creatine may prove useful in evaluating atrophy and recovery process of muscles.
Sponsorship	Magnetics Soc. of Japan Magnetics Soc. of the IEEE
Starting Page	1123
Ending Page	1124
File Size	166014
Page Count	2
File Format	PDF
ISBN	0780390091
DOI	10.1109/INTMAG.2005.1463991
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-04-04
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Muscles Atrophy Rats Magnetic resonance Spectroscopy Biochemistry Molecular biophysics Clinical diagnosis Diseases Performance evaluation
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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