NDLI: Functionalization of micro-Hall effect sensors for biomedical applications utilizing superparamagnetic beads

Content Provider	IEEE Xplore Digital Library
Author	Lapicki, A. Sanbonsugi, H. Yamamura, T. Matsushita, N. Abe, M. Narimatsu, H. Handa, H. Sandhu, A.
Copyright Year	2005
Description	Author affiliation: Quantum Nanoelectron. Res. Center, Tokyo, Japan (Lapicki, A.)
Abstract	This paper aims to meet demands of affordable and reliable analytical tools for detection, identification and quantification of DNA and other biomolecules. This work has two main objectives: (i) fabrication of Hall sensors that are compatible, with biological environment via a waterproof sensor passivation layer, insulation of electrical contacts, providing an interface for biomolecules, and suitable packaging; (ii) selection of highly selective biomolecular interactions for attachment of beads via specific target molecules. Practical applications of such sensors will depend on the optimal choice with regard to the specific combination of biochemical interactions securing immobilization of the microbeads to the sensor only when the selected target molecule is present in the analyte. Several variations of potentially practical schemes for immobilization have been reported in various contexts. In this study, this aspect was investigated for InSb micro-Hall sensors. The key issues identified were: the thiol-gold interaction for immobilization (direct or indirect) of probe molecules to the sensor surface; utilization of biochemical bonding between small molecules like biotin and large biomolecules like proteins or DNA; and finally extremely specific hybridization processes between complementary DNA fragments.
Sponsorship	Magnetics Soc. of Japan Magnetics Soc. of the IEEE
Starting Page	793
Ending Page	794
File Size	205954
Page Count	2
File Format	PDF
ISBN	0780390091
DOI	10.1109/INTMAG.2005.1463825
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-04-04
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biosensors DNA Molecular biophysics Fabrication Passivation Dielectrics and electrical insulation Contacts Packaging Biochemical analysis Probes
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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