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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Chengzhi Hu Nakajima, M. Yue, T. Shen, Y. Fukuda, T. Arai, F. Seki, M. |
| Copyright Year | 2013 |
| Description | Author affiliation: Dept. of Micro-nano Syst. Eng., Nagoya Univ., Nagoya, Japan (Chengzhi Hu; Nakajima, M.; Yue, T.; Shen, Y.; Fukuda, T.) || Dept. of Appl. Chem. & Biotechnol., Chiba Univ., Chiba, Japan (Seki, M.) || Dept. of Mech. Sci. & Eng., Nagoya Univ., Nagoya, Japan (Arai, F.) |
| Abstract | 3D tailor-made biodegradable scaffold integrated with biological cells or molecules is of great importance for tissue engineering. This paper addresses an improved method for exploring magnetic tweezers in patterning and aligning magnetic hydrogel fiber to fabricate large-scale engineered cell-hydrogel constructs. Magnetic hydrogel fibers were fabricated based on microfluidic device. The fabricated hydrogel fiber is made of alginic acid sodium and with a diameter of 34 μm. Magnetic nanoparticles is added into the alginic acid sodium solution to append magnetic material inside the fibers. The magnetic material inside the hydrogel fiber is regulated by the microfluidic device. Magnetic tweezers system based on solenoid electromagnet is utilized to evaluate the magnetic response of the magnetic hydrogel fiber. Evaluation results show the hydrogel fiber can be maneuvered by the proposed system with a positioning resolution of sub-micro level. The cultivation results of hydrogel fiber with C2C12 cells shows the potential for real applications of the proposed method in tissue engineering. |
| Sponsorship | IEEE Ind. Electron. Soc. |
| Starting Page | 2059 |
| Ending Page | 2064 |
| File Size | 832748 |
| Page Count | 6 |
| File Format | |
| ISSN | 21530858 |
| DOI | 10.1109/IROS.2013.6696632 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-11-03 |
| Publisher Place | Japan |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Magnetic resonance imaging Optical fiber devices Magnetic flux Magnetic levitation Magnetoacoustic effects Magnetic devices Microfluidics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Control and Systems Engineering Computer Science Applications Computer Vision and Pattern Recognition Software |
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