NDLI: Multiple microfluidic stream based manipulation for single cell handling

Content Provider	IEEE Xplore Digital Library
Author	Yalikun, Y. Akiyama, Y. Morishima, K.
Copyright Year	2013
Description	Author affiliation: Dept. of Mech. Eng., Osaka Univ., Ibaraki, Japan (Yalikun, Y.; Akiyama, Y.; Morishima, K.)
Abstract	This paper proposed a Multiple Microfluidic Stream based Manipulation (MMSM) for bio-objects using micro hydrodynamics and Lab on Chip (LOC) technology. Our method can manipulate bio-objects without contact under open space, the advantages of which were experimentally confirmed in this paper. Compared with other conventional bio-manipulation methods, this method is not directly in contact with the target bio-object, and was considered as a non-invasive and soft manipulation via hydrodynamic fluids. The basic principle of this system is manipulating a micro object by controlling several micro water streams which are generated from orifices under the operating area simultaneously. By changing the parameters of the water stream such as flow rates, position and number of operating orifices, the direction and velocity of the object can be controlled. To verify this principle, we designed an open space fluid model for on-chip manipulation, and simulated force and direction of the water stream using CFD software. Then the prototype microchip with an array of 8 orifices of diameter 100 μm, and 3 types of channels of widths 100 μm, 200 μm, and 500 μm respectively were fabricated with glass. In experiments several kinds of rectilinear motion of insect ovum and micro beads were observed. The results presented in this paper showed that this multi micro fluidic stream manipulation system has the capability for MMSM.
Sponsorship	IEEE Ind. Electron. Soc.
Starting Page	508
Ending Page	513
File Size	6988773
Page Count	6
File Format	PDF
ISSN	21530858
DOI	10.1109/IROS.2013.6696399
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-03
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Orifices Force Microfluidics Hydrodynamics Insects Mathematical model Fluidic microsystems
Content Type	Text
Resource Type	Article
Subject	Control and Systems Engineering Computer Science Applications Computer Vision and Pattern Recognition Software

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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