NDLI: Tumor targeting by computer controlled guidance of Magnetotactic Bacteria acting like autonomous microrobots

Content Provider	IEEE Xplore Digital Library
Author	Felfoul, Ouajdi Mohammadi, Mahmood Gaboury, Louis Martel, Sylvain
Copyright Year	2011
Description	Author affiliation: NanoRobotics Laboratory, Department of Computer and Software Engineering , École Polytechnique de Montréal, (Québec) Canada, H3C 3A7 (Felfoul, Ouajdi; Mohammadi, Mahmood; Martel, Sylvain) \|\| Institut de recherche en immunologie et en cancérologie (IRIC) Faculté de médecine, Université de Montréal, Canada (Gaboury, Louis)
Abstract	This paper reports the successful navigation of Magnetotactic Bacteria (MTB) towards regions located inside a solid tumor using a computer controlled set of magnetic coils. MTB uses two flagella bundles connected to rotary molecular motors as a propulsion system enabling them to reach swimming velocities of $300µm·s^{−1}$ without external source of power. Acting like autonomous microrobots, they can be remotely controlled by an appropriate magnetic guidance system as their swimming direction is predominantly determined by the direction of the ambient magnetic field. In order to cope with the harsh environment of the solid tumor and to bypass the lack of knowledge of the internal vessels architecture forming the route to the tumor, fundamental MTB motion properties are taken into account in addition to their ability to swim along the magnetic field. The studies revealed the presence of these bacteria in the necrotic zone of a solid tumor. Preliminary results suggest that not only the magnetic guidance can help enhancing the uniform distribution of MTB inside the tumor for therapeutic or diagnostic purposes, but the experimental data showed that they could perform accurately and efficiently under computer control, many of the tasks previously envisioned for future synthetic microrobots of only 1 to 2 micrometers in diameter and designed to operate in the human microvascular network.
Starting Page	1304
Ending Page	1308
File Size	411562
Page Count	5
File Format	PDF
ISBN	9781612844541
ISSN	21530858
e-ISBN	9781612844565
DOI	10.1109/IROS.2011.6094991
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-09-25
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microorganisms Tumors Magnetic resonance imaging Magnetic fields Torque Solids Navigation
Content Type	Text
Resource Type	Article
Subject	Control and Systems Engineering Computer Science Applications Computer Vision and Pattern Recognition Software

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