NDLI: Cellular energetic extension applied to the Luo-Rudy II ventricular cell model

Content Provider	IEEE Xplore Digital Library
Author	Szilagyi, S.M.
Copyright Year	2012
Description	Author affiliation: Petru Maior University, Tîrgu Mureş, Romania (Szilagyi, S.M.)
Abstract	The goal of this study is to introduce a new ventricular cell energetic model extension that, in contrast to earlier presented dynamic cell models, allows the simulation of long-term pathological events such as development of hypoxia and anoxia. We created an energetic ventricular cell model extension that involves the adenosine triphosphate (ATP)-adenosine diphosphate (ADP) cycling mechanism. We chose the well known Luo-Rudy II (LR) ventricular model and extended it with the developed energetic circulation system, so that we can easily validate the obtained results. The presence of hypoxia reduces the ATP concentration. In LR model a 10%/25%/50%/75% ATP concentration decrease subdued the ionic pumps efficiency by: 4%/14%/32%/55% for calcium pump of the sarcoplasmic reticulum; 3%/11%/26%/45% for external membranous calcium pump; 3%/10%/22%/39% for calcium sodium exchanger; and 2%/8%/18%/33% for sodium potassium exchanger. The malfunction of the calcium regulation mechanism is the principal danger factor in presence of hypoxia or anoxia and it is the most sensible element during ischemia.
Starting Page	857
Ending Page	860
File Size	213407
Page Count	4
File Format	PDF
ISBN	9781467320764
ISSN	2325887X
e-ISBN	9781467320771
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-09-09
Publisher Place	Poland
Access Restriction	Subscribed
Rights Holder	Creative Commons Attribution License 2.5 (CCAL)
Subject Keyword	Calcium Mathematical model Computational modeling Myocardium Electric potential Biological system modeling Pathology
Content Type	Text
Resource Type	Article
Subject	Computer Science Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hypoxia modeling using Luo-Rudy II cell model

Investigation of Myocardium Cell Membrane Properties on Luo-Rudy Mammalian Ventricular Model II

Cell and Tissue Responses to Electric Shocks Invited Paper

Modeling calcium dynamics in human atria

Computational analysis of extracellular calcium effects on an improved human ventricular action potential model

Recent human ventricular cell action potential models under varied ischaemic conditions

A novel computational sheep atria model for the study of atrial fibrillation

Luo and Rudy II : A Model of the Ventricular Action Potential 1113

A Model for Simulating Action Potential in Ventricular Cell

Cellular energetic extension applied to the Luo-Rudy II ventricular cell model

Similar Documents

Hypoxia modeling using Luo-Rudy II cell model

Investigation of Myocardium Cell Membrane Properties on Luo-Rudy Mammalian Ventricular Model II

Cell and Tissue Responses to Electric Shocks Invited Paper

Modeling calcium dynamics in human atria

Computational analysis of extracellular calcium effects on an improved human ventricular action potential model

Recent human ventricular cell action potential models under varied ischaemic conditions

A novel computational sheep atria model for the study of atrial fibrillation

Luo and Rudy II : A Model of the Ventricular Action Potential 1113

A Model for Simulating Action Potential in Ventricular Cell

Cellular energetic extension applied to the Luo-Rudy II ventricular cell model