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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Cantalapiedra, I.R. Lugo, C. Penaranda, A. Hove-Madsen, L. Echebarria, B. |
| Copyright Year | 2013 |
| Description | Author affiliation: Dept. de Fis. Aplic., Univ. Politec. de Catalunya, Barcelona, Spain (Cantalapiedra, I.R.; Lugo, C.; Penaranda, A.; Echebarria, B.) || Cardiovascular Res. Centre CSIC-ICCC, Hosp. de Sant Pau, Barcelona, Spain (Hove-Madsen, L.) |
| Abstract | Mathematical models of cardiac electrophysiology are an important tool to investigate the underlying mechanisms responsible of arrhythmias. In particular, an important question is the origin of atrial fibrillation (AF). Often, AF initiation is preceded by action potential duration (APD) alternans, i.e., beat to beat oscillations in the APD, that arise at slower rates in patients with persistent AF than in those without AF or with paroxymal AF. Most of these arrhythmias appear as a consequence of malfunctions in calcium dynamics that produce oscillations in intracellular calcium, inducing subsequent APD alternans through electromechanical coupling. The aim of this work is to present a human atrial mathematical model that gives insight into the presence of calcium alternans. For that the model by Nygren et al was modified in order to reproduce calcium alternans at high pacing rhythms, as has been observed in experiments. The model reproduces the nonlinear dependence of gain and fractional SR Ca release upon SR Ca load. At fast pacing rates it presents alternans, due to slow recovery from inactivation of the RyR. Finally, we compare the results from this new model with other human atrial models well established in the literature. |
| Sponsorship | IEEE Eng. Med. Biol. Soc. |
| Starting Page | 1071 |
| Ending Page | 1074 |
| File Size | 916510 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781479908844 |
| ISSN | 2325887X |
| e-ISBN | 9781479908868 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-09-22 |
| Publisher Place | Spain |
| Access Restriction | Subscribed |
| Rights Holder | Creative Commons Attribution License 2.5 (CCAL) |
| Subject Keyword | Calcium Mathematical model Computational modeling Transient analysis Load modeling Electric potential Oscillators |
| Content Type | Text |
| Resource Type | Article |
| Subject | Computer Science Cardiology and Cardiovascular Medicine |
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