NDLI: Modeling the mechanism of $[Na^{+}]i$ elevation in heart failure by a canine ventricular cell model

Content Provider	IEEE Xplore Digital Library
Author	Yunliang Zang Dongdong Deng Heqing Zhan Ling Xia
Copyright Year	2012
Description	Author affiliation: Department of Biomedical Engineering, Zhejiang University, Hangzhou, China (Yunliang Zang; Dongdong Deng; Heqing Zhan; Ling Xia)
Abstract	Numerous studies have found the phenomenon of $[Na^{+}]i$ elevation in cardiac myocytes in heart failure (HF), which may influence cardiac action potential (AP) and intracellular $Ca^{2+}$ handling to induce cardiac arrhythmias. As one of the most important regulators in the cardiac myocytes, $Ca^{2+}/Calmodulin-dependent$ protein kinase II (CaMKII), which could alter $Na^{+}$ channel gating, was found to be over-expressed in HF. It may contribute to $[Na^{+}]i$ elevation in HF. For the purpose of this study, we developed a new canine epicardial cell model based on the framework of published Hund-Rudy dynamic (HRd) model. The effects of dynamic CaMKII regulation on fast $Na^{+}$ current (INa) and late $Na^{+}$ current (INaL) were incorporated into our model according to the recent experimental data. Simulation results suggested that the regulation role of CaMKII on INaL could elevate $[Na^{+}]i.$ The effect of COE on INa had a function of lowering $[Na^{+}]i$ in fact. However, it could not offset the trend of $Na^{+}$ up-regulation by enhanced INaL. The magnitude of $[Na^{+}]i$ elevation was smaller than experimentally measured values. We speculate that other $[Na^{+}]i$ elevation mechanisms such as lowered $Na^{+}/K^{+}$ pump (INaK) or increased $Na^{+}/H^{+}$ exchange may happen in HF.
Starting Page	237
Ending Page	240
File Size	257116
Page Count	4
File Format	PDF
ISBN	9781467320764
ISSN	2325887X
e-ISBN	9781467320771
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-09-09
Publisher Place	Poland
Access Restriction	Subscribed
Rights Holder	Creative Commons Attribution License 2.5 (CCAL)
Subject Keyword	Heart Kinetic theory Proteins Transient analysis Indium tin oxide Rabbits Biomedical engineering
Content Type	Text
Resource Type	Article
Subject	Computer Science Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in