NDLI: Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model

Content Provider	IEEE Xplore Digital Library
Author	Sanchez, C. Krueger, M.W. Seemann, G. Dossel, O. Pueyo, E. Rodriguez, B.
Copyright Year	2012
Description	Author affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany (Krueger, M.W.; Seemann, G.; Dossel, O.) \|\| Computational Biology Group, Oxford University Department of Computer Science, Oxford, UK (Rodriguez, B.) \|\| Communications Technology Group, I3A, University of Zaragoza, Zaragoza, Spain (Sanchez, C.) \|\| Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, (CIBER-BBN), Spain (Pueyo, E.)
Abstract	Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is mainly sustained by reentrant circuits and rapid ectopic activity. In the present study, we performed computer simulations using a 3D human atrial model including fibre orientation, electrophysiological heterogeneities and tissue anisotropy. Membrane kinetics were described as in the human atrial action potential model by Maleckar et al., including AF-induced ionic remodeling. The impact of ionic changes on reentrant activity was investigated by characterizing arrhythmia stability, rotor dynamics and dominant frequency (DF). Our simulations show that reentrant circuits tend to organize around the pulmonary veins and the right atrial appendage. Simulated IK1 and INa blocks lead to slower DF in the whole atria, expanded wave meandering and reduction of secondary wavelets. INaK block slightly reduces DF and does not notably change the propagation pattern. Regularity and coupling indices of electrograms are usually higher in the right atrium than in the left atrium, entailing a higher likelihood of arrhythmia generation in the latter, as occurs in AF patients.
Starting Page	137
Ending Page	140
File Size	677517
Page Count	4
File Format	PDF
ISBN	9781467320764
ISSN	2325887X
e-ISBN	9781467320771
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-09-09
Publisher Place	Poland
Access Restriction	Subscribed
Rights Holder	Creative Commons Attribution License 2.5 (CCAL)
Subject Keyword	Rotors Humans Computational modeling Solid modeling Organizations Integrated circuit modeling Couplings
Content Type	Text
Resource Type	Article
Subject	Computer Science Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cell repolarization variability modulates atrial fibrillation dynamics in 3D virtual human atria

Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model

Cardioversion using feedback stimuli in human atria

Approximate entropy can localize rotors, but not ectopic foci during chronic atrial fibrillation: A simulation study

Simulated atrial fibrillation in a computer model of human atria

The ionic expression gradients affect paroxysmal atrial fibrillation dynamics: A simulation study

Influence of left atrial geometry on rotor core trajectories in a model of atrial fibrillation

A novel computational sheep atria model for the study of atrial fibrillation

Influence of transmural slow-conduction zones on the long-time behaviour of atrial arrhythmia: A numerical study with a human bilayer atrial model

Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model

Similar Documents

Cell repolarization variability modulates atrial fibrillation dynamics in 3D virtual human atria

Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model

Cardioversion using feedback stimuli in human atria

Approximate entropy can localize rotors, but not ectopic foci during chronic atrial fibrillation: A simulation study

Simulated atrial fibrillation in a computer model of human atria

The ionic expression gradients affect paroxysmal atrial fibrillation dynamics: A simulation study

Influence of left atrial geometry on rotor core trajectories in a model of atrial fibrillation

A novel computational sheep atria model for the study of atrial fibrillation

Influence of transmural slow-conduction zones on the long-time behaviour of atrial arrhythmia: A numerical study with a human bilayer atrial model

Ionic modulation of atrial fibrillation dynamics in a human 3D atrial model