NDLI: Elucidating the body surface P-wave using a detailed computer model of atrial activation

Content Provider	IEEE Xplore Digital Library
Author	Colman, M.A. Giacopelli, D. Langley, P. Henggui Zhang
Copyright Year	2012
Description	Author affiliation: University of Manchester, Manchester, UK (Colman, M.A.; Henggui Zhang) \|\| Newcastle University, Newcastle, UK (Giacopelli, D.; Langley, P.)
Abstract	Features of the ECG P-wave remain largely unexplained. P-wave notching is thought to relate to distinct events of right and left atrial activations. Wandering pacemaker is known to give rise to distinct P wave morphologies. In this study, we develop a 3D computational model of the human atria that is incorporated into a 3D human torso model which can simulate realistic P-waves across the torso. The atrial model considered detailed anatomical structure and electrophysiological heterogeneity. The torso model is used to produce ECG P-waves corresponding to those of the standard 12 lead ECG as well as a more detailed 64 lead electrode vest. The model is validated both in terms of the atrial activation sequence and the P-waves produced. The 12 lead ECG is then used to detect the presence of acetylcholine and isoprenaline on the atria. The 64 lead vest simulation is used to confirm that the presence of distinct P-wave modes in a clinical ECG is likely due to the presence of a leading pacemaker site shift, which may be caused by acetylcholine.
Starting Page	129
Ending Page	132
File Size	546184
Page Count	4
File Format	PDF
ISBN	9781467320764
ISSN	2325887X
e-ISBN	9781467320771
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-09-09
Publisher Place	Poland
Access Restriction	Subscribed
Rights Holder	Creative Commons Attribution License 2.5 (CCAL)
Subject Keyword	Electrocardiography Pacemakers Humans Torso Computational modeling ISO Mathematical model
Content Type	Text
Resource Type	Article
Subject	Computer Science Cardiology and Cardiovascular Medicine

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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