NDLI: Quantification of spatial repolarization heterogeneity: Testing the robustness of a new technique

Content Provider	IEEE Xplore Digital Library
Author	Sassi, R. Mainardi, L.T.
Copyright Year	2012
Description	Author affiliation: Dipartimento di Informatica, Università degli Studi di Milano, Italy (Sassi, R.) \|\| Dipartimento di Bioingegneria, Politecnico di Milano, Italy (Mainardi, L.T.)
Abstract	The V-index is a recently-proposed metric related to repolarization heterogeneity (RH) across the myocardium, a key quantity for the development of arrhythmias. The metric is derived from multi-leads ECG recordings and this paper investigates two of its properties: i) the dependency on the lead system (Frank's orthogonal vs. 12 standard leads); ii) the influence of errors in the location of the T-end position. The first investigation was performed by simulations, using a forward ECG model (ECGSIM). In the lead system of interest, the V-index was computed varying the standard deviation of RH (sv). The results showed that the average bias in the estimate of RH (at σϕ = 1 ms) ranged from −20.4±4.0% (sv = 20.6 ms) to −26.3±4.0% (sv = 70.9 ms) for the standard system and from −7.0 ± 4.2% to − 19.0 ± 4.2% for the Frank's one. While the bias diminished, the vulnerability to noise slightly increased. Secondarily, 68 ECGs from the E-OTH-12-0068-010 THEW database were analyzed. To simulate mislocation, the T-end point was consistently moved (±20 ms) around its correct position and the V-index computed. The average differences in the V-index estimates across the population were always smaller than 1%. This is a desirable property, given the discrepancies across methods in locating T-end positions.
Starting Page	69
Ending Page	72
File Size	248678
Page Count	4
File Format	PDF
ISBN	9781467320764
ISSN	2325887X
e-ISBN	9781467320771
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-09-09
Publisher Place	Poland
Access Restriction	Subscribed
Rights Holder	Creative Commons Attribution License 2.5 (CCAL)
Subject Keyword	Electrocardiography Standards Noise Indexes Myocardium Delay
Content Type	Text
Resource Type	Article
Subject	Computer Science Cardiology and Cardiovascular Medicine

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