NDLI: On the modeling of drug induced respiratory depression in the non-steady-state

Content Provider	IEEE Xplore Digital Library
Author	Caruso, Antonello L.G. Bouillon, Thomas W. Schumacher, Peter M. Morari, Manfred
Copyright Year	2008
Description	Author affiliation: Modeling and Simulation Group at Novartis Pharma AG, CH - 4056 Basel, Switzerland (Bouillon, Thomas W.) \|\| Department of Anesthesiology, University Hospital (Inselspital), CH-3010 Bern, Switzerland (Schumacher, Peter M.) \|\| Anesthesia Control Group at the Automatic Control Laboratory, ETH Zurich, CH-8092, Switzerland (Caruso, Antonello L.G.; Morari, Manfred)
Abstract	The ability of anesthetic agents to provide adequate analgesia and sedation is limited by the ventilatory depression associated with overdosing in spontaneously breathing patients. Therefore, quantitation of drug induced ventilatory depression is a pharmacokinetic-pharmacodynamic problem relevant to the practice of anesthesia. Although several studies describe the effect of respiratory depressant drugs on isolated endpoints, an integrated description of drug induced respiratory depression with parameters identifiable from clinically available data is not available. This study proposes a physiological model of CO2 disposition, ventilatory regulation, and the effects of anesthetic agents on the control of breathing. The predictive performance of the model is evaluated through simulations aimed at reproducing experimental observations of drug induced hypercarbia and hypoventilation associated with intravenous administration of a fast-onset, highly potent anesthetic mu agonist (including previously unpublished experimental data determined after administration of 1 mg alfentanil bolus). The proposed model structure has substantial descriptive capability and can provide clinically relevant predictions of respiratory inhibition in the non-steady-state to enhance safety of drug delivery in the anesthetic practice.
Starting Page	5564
Ending Page	5568
File Size	262490
Page Count	5
File Format	PDF
ISBN	9781424418145
ISSN	1557170X
DOI	10.1109/IEMBS.2008.4650475
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-08-20
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	drug induced respiratory depression regulation of breathing hypercarbic and hypoxic respiratory drive pharmacodynamic modeling
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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