NDLI: Reliability of cluster results for different types of time adjustments in complex disease research

Content Provider	IEEE Xplore Digital Library
Author	Colas, Fabrice Meulenbelt, Ingrid Houwing-Duistermaat, Jeanine J. Kloppenburg, Margreet Watt, Iain van Rooden, Stephanie M. Visser, Martine Marinus, Johan van Hilten, Jacobus J. Slagboom, P. Eline Kok, Joost N.
Copyright Year	2008
Description	Author affiliation: Department of Neurology, Leiden University Medical Center, THE NETHERLANDS (van Rooden, Stephanie M.; Visser, Martine; Marinus, Johan; van Hilten, Jacobus J.) \|\| MOLEPI, Leiden University Medical Center, THE NETHERLANDS (Meulenbelt, Ingrid; Slagboom, P. Eline) \|\| Department of Radiology, Leiden University Medical Center, THE NETHERLANDS (Watt, Iain) \|\| LIACS, Leiden University, THE NETHERLANDS (Colas, Fabrice; Kok, Joost N.) \|\| MEDSTATS, Leiden University Medical Center, THE NETHERLANDS (Houwing-Duistermaat, Jeanine J.) \|\| Department of Rheumatology, Leiden University Medical Center, THE NETHERLANDS (Kloppenburg, Margreet)
Abstract	We aim to identify subtypes of diseases like Osteoarthritis (OA) and Parkinson's Disease (PD) that present clinical heterogeneity. We do so by searching for homogeneous clusters in values of markers that reflect the severity of the disease. In the current paper we consider two important items for a cluster analysis. First, as time can contribute largely to the measured variability in the data, we search for the most appropriate way to adjust for it. Second, as we aim for reliable cluster analyses, cluster results should exhibit robustness to little change in the data. To investigate these issues, we transform the data by adding noise of different levels before cluster modeling and we rely on a $χ^{2}-based$ measure of association to compare cluster results for different types of time adjustment. The results of our experiments suggest to adjust data for a logarithmic age effect for OA and a square root effect of the disease duration for PD because these adjustments lead more reliable cluster results.
Starting Page	4601
Ending Page	4604
File Size	210280
Page Count	4
File Format	PDF
ISBN	9781424418145
ISSN	1557170X
DOI	10.1109/IEMBS.2008.4650238
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-08-20
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Reliability of cluster results for different types of time adjustments in complex disease research

Women in Biomedical Engineering and Health Informatics

Unintentional balance destabilization system reliability studies

Quantifying time awake posturographically

Sparse representation of complex MRI images

Identification of Genes for Complex Diseases by Integrating Multiple Types of Genomic Data

Ethics in Biomedical Engineering

EVestG™: A measure for Meniere's Disease

Precise prediction for managing chronic disease readmissions

Reliability of cluster results for different types of time adjustments in complex disease research

Similar Documents

Reliability of cluster results for different types of time adjustments in complex disease research

Women in Biomedical Engineering and Health Informatics

Unintentional balance destabilization system reliability studies

Quantifying time awake posturographically

Sparse representation of complex MRI images

Identification of Genes for Complex Diseases by Integrating Multiple Types of Genomic Data

Ethics in Biomedical Engineering

EVestG™: A measure for Meniere's Disease

Precise prediction for managing chronic disease readmissions

Reliability of cluster results for different types of time adjustments in complex disease research