NDLI: An islet population model of pancreatic insulin production

Content Provider	IEEE Xplore Digital Library
Author	De Gaetano, A. Gaz, C. Gori Giorgi, C. Palumbo, P.
Copyright Year	2013
Description	Author affiliation: Dept. of Comput., Control, & Manage. Eng. (DIAG), Sapienza Univ. di Roma, Rome, Italy (Gori Giorgi, C.) \|\| Ist. di Anal. dei Sist. ed Inf. "A. Ruberti", Rome, Italy (De Gaetano, A.; Gaz, C.; Palumbo, P.)
Abstract	Glucose-induced pancreatic insulin release is the fundamental mechanism responsible for glucose homeostasis, its failure determining the clinical picture of Diabetes Mellitus. The details of the feedback loop controlling glycemia through insulin secretion have been an important subject of investigation and modeling for decades. In this note, a recently published population model is considered, whose purpose is to replicate in silico different observed phenomena such as low frequency glycemia-insulinemia oscillations, as well as concordant induction of high-frequency insulin oscillations. The basic idea underlying this model is that the pancreas behaves like a population of independent controllers (each consisting of a fundamental secreting unit, a pancreatic islet), all reacting to the same glucose stimulus, but with varying performance characteristics. This idea has been supported by a relatively wide range of simulations, aiming to replicate most important in vivo experiments concerning pancreatic insulin release. It will be shown in this note that the same mathematical structure can also replicate a set of in vitro experiments, provided that the model context is adapted to the structure of the different experiments to be simulated. More in details, the model will be shown to reproduce the double phase of insulin release during a prolonged glucose stimulus: a first phase of impulsive insulin release, immediately upon glucose administration, and a second phase of more gradual release, dependent on the potentiation effect of the secretory units.
Sponsorship	IEEE Control Syst. Soc.
Starting Page	3355
Ending Page	3360
File Size	271006
Page Count	6
File Format	PDF
ISBN	9781467357142
ISSN	07431546
e-ISBN	9781467357173
DOI	10.1109/CDC.2013.6760396
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-12-10
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Insulin Sugar Sociology Statistics Mathematical model Pancreas Plasmas
Content Type	Text
Resource Type	Article
Subject	Control and Optimization Control and Systems Engineering Modeling and Simulation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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