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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Pichl, L. Tachikawa, M. Buenker, R.J. Kimura, M. Rost, J.-M. |
| Copyright Year | 1963 |
| Abstract | The angular correlation distribution of electron-positron annihilation photons is presented for polar biological molecules, and the associated noncollinearity effect on resolution in positron emission tomography (PET) is discussed. The image resolution in PET is known to be limited by a number of factors such as radioactive decay statistics, attenuation, scatter, or random coincidence of annihilation photons. This paper deals with the resolution limits on the side of the measured system. Our calculated distribution of annihilation momentum belongs to the intrinsic resolution factors together with the positron range in biological tissue; the other factors are due to the interactions along the photon path from the tissue to the detector. Here we demonstrate that the angular distribution of annihilation trajectories is not necessarily Gaussian, especially when the positron temporarily binds in a molecular dipole moment field before annihilation. The theoretical framework treats the electron and positron on the same footing by using the multireference single- and double-excitation configuration interaction algorithms applicable also to other bound-state systems. Our results form a subset of parameters relevant to the statistical image reconstruction algorithms, which may eventually increase the sensitivity of PET imaging in clinical setting |
| Sponsorship | IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD |
| Starting Page | 2810 |
| Ending Page | 2817 |
| Page Count | 8 |
| File Size | 914237 |
| File Format | |
| ISSN | 00189499 |
| Volume Number | 52 |
| Issue Number | 6 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2005-12-01 |
| Publisher Place | U.S.A. |
| Access Restriction | One Nation One Subscription (ONOS) |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Molecular biophysics Positron emission tomography Biological tissues Single photon emission computed tomography Image resolution Radioactive decay Statistical distributions Attenuation Electromagnetic scattering Particle scattering positron emission tomography (PET) resolution Angular correlation of annihilation distribution measurements (ACAR) carbonyl group dipole-bound positron states multireference single- and double-excitation configuration interaction (MRD-CI) image reconstruction |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering |
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