NDLI: Neutrophils ameliorate lung injury and the development of severe disease during influenza infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Anderson, Gary P. Tate, Michelle D. Deng, Yi-Mo Brooks, Andrew G. Reading, Patrick C. Jones, Jessica E.
Description	Country affiliation: Australia Author Affiliation: Tate MD ( Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia.)
Abstract	The clinical response to influenza infection ranges from mild disease to severe pneumonia and it remains unclear whether the inflammatory response to infection is protective or pathogenic. We have defined a novel role for neutrophils in ameliorating lung injury during influenza infection, thereby limiting development of severe disease. Infection of neutrophil-depleted mice with influenza virus HKx31 (H3N2) led to rapid weight loss, pneumonia, and death. Neutropenia was associated with enhanced virus replication in the respiratory tract; however, viral titers were declining at the time of death, leading us to investigate other factors contributing to mortality. In addition to thymic atrophy, lymphopenia, and viremic spread, depletion of neutrophils led to exacerbated pulmonary inflammation, edema, and respiratory dysfunction. Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	183
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2009-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Influenza A Virus, H3n2 Subtype Immunology Neutrophils Orthomyxoviridae Infections Pneumonia, Viral Animals Mice Mice, Inbred C57bl Pathology Virology Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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