NDLI: Immune gene and cell enrichment is associated with a good prognosis in ependymoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Michael Handler, Michael H. Wei, Qi Waziri, Allen E. Barton, Valerie N. Donson, Andrew M. Foreman, Nicholas K. Birks, Diane K. Kleinschmidt-Demasters, Bette K.
Description	Country affiliation: United States Author Affiliation: Donson AM ( Department of Pediatrics, University of Colorado Denver, Mail Stop 8302, P.O. Box 6511, Aurora, CO 80045, USA. andrew.donson@ucdenver.edu)
Abstract	Approximately 50% of children with ependymoma will suffer from tumor recurrences that will ultimately lead to death. Development of more effective therapies and patient stratification in ependymoma mandates better prognostication. In this study, tumor gene expression microarray profiles from pediatric ependymoma clinical samples were subject to ontological analyses to identify outcome-associated biological factors. Histology was subsequently used to evaluate the results of ontological analyses. Ontology analyses revealed that genes associated with nonrecurrent ependymoma were predominantly immune function-related. Additionally, increased expression of immune-related genes was correlated with longer time to progression in recurrent ependymoma. Of those genes associated with both the nonrecurrent phenotype and that positively correlated with time to progression, 95% were associated with immune function. Histological analysis of a subset of these immune function genes revealed that their expression was restricted to a subpopulation of tumor-infiltrating cells. Analysis of tumor-infiltrating immune cells showed increased infiltration of CD4(+) T cells in the nonrecurrent ependymomas. No genomic sequences for SV40, BK, JC, or Merkel polyomaviruses were found in nonrecurrent ependymoma. This study reveals that up-regulation of immune function genes is the predominant ontology associated with a good prognosis in ependymoma and it provides preliminary evidence of a beneficial host proinflammatory and/or Ag-specific immune response.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	183
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2009-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Neoplasms Genetics Immunology Ependymoma Gene Expression Profiling Adolescent Tumor Markers, Biological Child, Preschool Gene Expression Infant Lymphocytes, Tumor-infiltrating Neoplasm Recurrence, Local Oligonucleotide Array Sequence Analysis Prognosis Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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