NDLI: MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation.

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MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation.

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MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Degn, Søren E. Jacobsen, Christian Jensenius, Jens C. Steffensen, Rudi Thiel, Steffen Hansen, Annette G.
Description	Country affiliation: Denmark Author Affiliation: Degn SE ( Departments of Medical Microbiology and Immunology, University of Aarhus, Arhus, Denmark.)
Abstract	Essential effector functions of innate immunity are mediated by complement activation initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL) and the ficolins. We present a novel, phylogenetically conserved protein, MAp44, which is found in human serum at 1.4 microg/ml in Ca(2+)-dependent complexes with the soluble pattern recognition molecules. The affinity for MBL is in the nanomolar range (K(D) = 0.6 nM) as determined by surface plasmon resonance. The first eight exons of the gene for MAp44 encode four domains shared with MBL-associated serine protease (MASP)-1 and MASP-3 (CUB1-EGF-CUB2-CCP1), and a ninth exon encodes C-terminal 17 aa unique to MAp44. mRNA profiling in human tissues shows high expression in the heart. MAp44 competes with MASP-2 for binding to MBL and ficolins, resulting in inhibition of complement activation. Our results add a novel mechanism to those known to control the innate immune system.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	183
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2009-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Isoenzymes Genetics Metabolism Mannose-binding Protein-associated Serine Proteases Amino Acid Sequence Animals Complement Activation Electrophoresis, Polyacrylamide Gel Lectins Mannose-binding Lectin Molecular Sequence Data Phylogeny Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Surface Plasmon Resonance Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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