NDLI: Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism.

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Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism.

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Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ishikawa, Izumi Arita, Makoto Inoue, Asuka Nagasawa, Risa Hashimoto, Eri Suzuki, Yuji Kunisawa, Jun Shikata, Shiori Aoki, Junken Kiyono, Hiroshi
Description	Author Affiliation: Kunisawa J ( Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan); Hashimoto E ( Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan); Inoue A ( International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan); Nagasawa R ( Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan); Suzuki Y ( Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan); Ishikawa I ( Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan); Shikata S ( Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan); Arita M ( Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan); Aoki J ( Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan); Kiyono H ( Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan)
Abstract	Enhancement of intestinal IgA responses is a primary strategy in the development of oral vaccine. Dietary fatty acids are known to regulate host immune responses. In this study, we show that dietary palmitic acid (PA) and its metabolites enhance intestinal IgA responses. Intestinal IgA production was increased in mice maintained on a PA-enriched diet. These mice also showed increased intestinal IgA responses against orally immunized Ag, without any effect on serum Ab responses. We found that PA directly stimulates plasma cells to produce Ab. In addition, mice receiving a PA-enriched diet had increased numbers of IgA-producing plasma cells in the large intestine; this effect was abolished when serine palmitoyltransferase was inhibited. These findings suggest that dietary PA regulates intestinal IgA responses and has the potential to be a diet-derived mucosal adjuvant.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	4
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-08-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dietary Fats Metabolism Immunoglobulin A Immunology Intestinal Mucosa Palmitic Acid Adjuvants, Immunologic Animals Cells, Cultured Cholera Toxin Dietary Supplements Fatty Acids, Monounsaturated Immunity, Mucosal Blood Immunoglobulin G Mice Mice, Inbred Balb C Mice, Inbred C3h Ovalbumin Administration & Dosage Plant Oils Plasma Cells Serine C-palmitoyltransferase Antagonists & Inhibitors Soybean Oil Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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