NDLI: Distinct FcÎ³ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation.

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Distinct FcÎ³ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cox, Nehemiah Pilling, Darrell Gomer, Richard H.
Description	Author Affiliation: Cox N ( Department of Biology, Texas A&M University, College Station, TX 77843.); Pilling D ( Department of Biology, Texas A&M University, College Station, TX 77843.); Gomer RH ( Department of Biology, Texas A&M University, College Station, TX 77843 rgomer@tamu.edu.)
Abstract	The plasma protein serum amyloid P (SAP) reduces neutrophil adhesion, inhibits the differentiation of monocytes into fibroblast-like cells called fibrocytes, and promotes phagocytosis of cell debris by macrophages. Together, these effects of SAP reduce key aspects of inflammation and fibrosis, and SAP injections improve lung function in pulmonary fibrosis patients. SAP functions are mediated, in part, by FcÎ³Rs, but the contribution of each FcÎ³R is not fully understood. We found that aa Q55 and E126 in human SAP affect human fibrocyte differentiation and SAP binding to FcÎ³RI. E126, K130, and Q128 affect neutrophil adhesion and SAP affinity for FcÎ³RIIa. Q128 also affects phagocytosis by macrophages and SAP affinity for FcÎ³RI. All the identified functionally significant amino acids in SAP form a binding site that is distinct from the previously described SAP-FcÎ³RIIa binding site. Blocking FcÎ³RI with an IgG-blocking Ab reduces the SAP effect on fibrocyte differentiation, and ligating FcÎ³RIIa with Abs reduces neutrophil adhesion. Together, these results suggest that SAP binds to FcÎ³RI on monocytes to inhibit fibrocyte differentiation, and binds to FcÎ³RIIa on neutrophils to reduce neutrophil adhesion.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1400281
Journal	The Journal of Immunology
Issue Number	4
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-08-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Neutrophils Immunology Receptors, Igg Serum Amyloid P-component Amino Acid Sequence Antibodies, Blocking Binding Sites, Antibody Cell Adhesion Cell Differentiation Cells, Cultured Fibroblasts Fibrosis Hek293 Cells Immunoglobulin G Inflammation Macrophages Monocytes Phagocytosis Protein Isoforms Genetics Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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