NDLI: Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Jianing Wang, Yu Tang, Lihua de Villiers, Willem J. S. Cohen, Donald Woodward, Jerold Finkelman, Fred D. Eckhardt, Erik R. M.
Description	Country affiliation: United States Author Affiliation: Li J ( Graduate Center for Nutritional Sciences and Internal Medicine Department, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, Ky 40536-0200, USA.)
Abstract	BACKGROUND: The prevalence of peanut allergies is increasing. Peanuts and many other allergen sources contain significant amounts of triglycerides, which affect absorption of antigens but have unknown effects on sensitization and anaphylaxis. We recently reported that dietary medium-chain triglycerides (MCTs), which bypass mesenteric lymph and directly enter portal blood, reduce intestinal antigen absorption into blood compared with long-chain triglycerides (LCTs), which stimulate mesenteric lymph flow and are absorbed in chylomicrons through mesenteric lymph. OBJECTIVE: We sought to test how dietary MCTs affect food allergy. METHODS: C3H/HeJ mice were fed peanut butter protein in MCT, LCT (peanut oil), or LCT plus an inhibitor of chylomicron formation (Pluronic L81). Peanut-specific antibodies in plasma, responses of the mice to antigen challenges, and intestinal epithelial cytokine expression were subsequently measured. RESULTS: MCT suppressed antigen absorption into blood but stimulated absorption into Peyer patches. A single gavage of peanut protein with MCT, as well as prolonged feeding in MCT-based diets, caused spontaneous allergic sensitization. MCT-sensitized mice experienced IgG-dependent anaphylaxis on systemic challenge and IgE-dependent anaphylaxis on oral challenge. MCT feeding stimulated jejunal-epithelial thymic stromal lymphopoietin, Il25, and Il33 expression compared with that seen after LCT feeding and promoted T(H)2 cytokine responses in splenocytes. Moreover, oral challenges of sensitized mice with antigen in MCT significantly aggravated anaphylaxis compared with challenges with the LCT. Importantly, the effects of MCTs could be mimicked by adding Pluronic L81 to LCTs, and in vitro assays indicated that chylomicrons prevent basophil activation. CONCLUSION: Dietary MCTs promote allergic sensitization and anaphylaxis by affecting antigen absorption and availability and by stimulating T(H)2 responses.
File Format	HTM / HTML
ISSN	00916749
e-ISSN	10976825
DOI	10.1016/j.jaci.2012.10.011
Journal	Journal of Allergy and Clinical Immunology
Issue Number	2
Volume Number	131
Language	English
Publisher	Elsevier
Publisher Date	2013-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Immunology Anaphylaxis Immunology Arachis Hypogaea Peanut Hypersensitivity Triglycerides Allergens Metabolism Animals Antibodies Antigens Chemistry Basophils Chylomicrons Cytokines Diet Immunoglobulin E Immunoglobulin G Interleukins Intestinal Absorption Intestinal Mucosa Jejunum Mice Mice, Inbred Balb C Mice, Inbred C3h Rats, Sprague-dawley Th2 Cells Administration & Dosage Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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