NDLI: Adipocyte IL-15 regulates local and systemic NK cell development.

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Adipocyte IL-15 regulates local and systemic NK cell development.

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Adipocyte IL-15 regulates local and systemic NK cell development.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tsai, Ching-Yen Wang, Szu-Wen Chang, Chin-Ling Hou, Mau-Sheng Lee, Gilbert Aaron Liou, Yae-Huei Jiang, Si-Tse Lai, Yein-Gei Huang, Po-Lin Liao, Nan-Shih
Description	Country affiliation: Taiwan Author Affiliation: Liou YH ( Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan); Wang SW ( Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.); Chang CL ( Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.); Huang PL ( Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.); Hou MS ( Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.); Lai YG ( Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.); Lee GA ( Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.); Jiang ST ( Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.); Tsai CY ( Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.); Liao NS ( Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan)
Abstract	NK cell development and homeostasis require IL-15 produced by both hematopoietic and parenchymal cells. Certain hematopoietic IL-15 sources, such as macrophages and dendritic cells, are known, whereas the source of parenchymal IL-15 remains elusive. Using two types of adipocyte-specific Il15(-/-) mice, we identified adipocytes as a parenchymal IL-15 source that supported NK cell development nonredundantly. Both adipocyte-specific Il15(-/-) mice showed reduced IL-15 production specifically in the adipose tissue but impaired NK cell development in the spleen and liver in addition to the adipose tissue. We also found that the adipose tissue harbored NK progenitors as other niches (e.g. spleen) for NK cell development, and that NK cells derived from transplanted adipose tissue populated the recipient's spleen and liver. These findings suggest that adipocyte IL-15 contributes to systemic NK cell development by supporting NK cell development in the adipose tissue, which serves as a source of NK cells for other organs.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	4
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-08-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adipocytes Cytology Cell Differentiation Immunology Interleukin-15 Killer Cells, Natural Transplantation Adipose Tissue Adoptive Transfer Animals Bone Marrow Cells Dendritic Cells Homeostasis Genetics Liver Macrophages Mice Mice, Inbred C57bl Mice, Knockout Nk Cell Lectin-like Receptor Subfamily A Biosynthesis Rna, Messenger Receptors, Immunologic Spleen Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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