NDLI: Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

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Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

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Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Balan, Sreekumar Shaw, Michael Colletti, Nicholas Savoret, Juliette Soos, Timothy Sanchez, Cindy Liu, Hong Fossum, Even Asselin-Paturel, Carine Chelbi, Rabie Montanana-Sanchis, Frédéric Perrot, Ivan Bogen, Bjarne Caux, Christophe Doffin, Anne-Claire Valladeau-Guilemond, Jenny Vu Manh, Thien-Phong Chabannon, Christian Ollion, Vincent Bechlian, Didier Dalod, Marc
Description	Author Affiliation: Balan S ( Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France); Ollion V ( Institut des Sciences Pharmaceutiques et Biologiques, Université Lyon 1, Université de Lyon, 69373 Lyon, France); Colletti N ( Sanofi, Cambridge, MA 02139); Chelbi R ( Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France); Montanana-Sanchis F ( Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France); Liu H ( Sanofi, Cambridge, MA 02139); Vu Manh TP ( Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France); Sanchez C ( Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France); Savoret J ( Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France); Perrot I ( Innate-Pharma, 13009 Marseille, France); Doffin AC ( Institut des Sciences Pharmaceutiques et Biologiques, Université Lyon 1, Université de Lyon, 69373 Lyon, France); Fossum E ( K.G. Jebsen Center for Research on Influenza Vaccines, University of Oslo and Oslo University Hospital, 0027 Oslo, Norway); Bechlian D ( Institut Paoli-Calmettes, 13009 Marseille, France); Chabannon C ( Institut Paoli-Calmettes, 13009 Marseille, France); Bogen B ( K.G. Jebsen Center for Research on Influenza Vaccines, University of Oslo and Oslo University Hospital, 0027 Oslo, Norway); Asselin-Paturel C ( Innate-Pharma, 13009 Marseille, France); Shaw M ( Sanofi, Cambridge, MA 02139); Soos T ( Sanofi, Cambridge, MA 02139); Caux C ( Institut des Sciences Pharmaceutiques et Biologiques, Université Lyon 1, Université de Lyon, 69373 Lyon, France); Valladeau-Guilemond J ( Institut des Sciences Pharmaceutiques et Biologiques, Université Lyon 1, Université de Lyon, 69373 Lyon, France); Dalod M ( Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France)
Abstract	Human monocyte-derived dendritic cell (MoDC) have been used in the clinic with moderately encouraging results. Mouse XCR1(+) DC excel at cross-presentation, can be targeted in vivo to induce protective immunity, and share characteristics with XCR1(+) human DC. Assessment of the immunoactivation potential of XCR1(+) human DC is hindered by their paucity in vivo and by their lack of a well-defined in vitro counterpart. We report in this study a protocol generating both XCR1(+) and XCR1(-) human DC in CD34(+) progenitor cultures (CD34-DC). Gene expression profiling, phenotypic characterization, and functional studies demonstrated that XCR1(-) CD34-DC are similar to canonical MoDC, whereas XCR1(+) CD34-DC resemble XCR1(+) blood DC (bDC). XCR1(+) DC were strongly activated by polyinosinic-polycytidylic acid but not LPS, and conversely for MoDC. XCR1(+) DC and MoDC expressed strikingly different patterns of molecules involved in inflammation and in cross-talk with NK or T cells. XCR1(+) CD34-DC but not MoDC efficiently cross-presented a cell-associated Ag upon stimulation by polyinosinic-polycytidylic acid or R848, likewise to what was reported for XCR1(+) bDC. Hence, it is feasible to generate high numbers of bona fide XCR1(+) human DC in vitro as a model to decipher the functions of XCR1(+) bDC and as a potential source of XCR1(+) DC for clinical use.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1401243
Journal	The Journal of Immunology
Issue Number	4
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-08-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd34 Immunology Blood Cells Dendritic Cells Monocytes Receptors, G-protein-coupled Adjuvants, Immunologic Pharmacology Antigen Presentation Cell Culture Techniques Cell Differentiation Cell Line Cross-priming Gene Expression Profiling Green Fluorescent Proteins Imidazoles Killer Cells, Natural Lipopolysaccharides Phenotype Poly I-c T-lymphocytes Toll-like Receptor 3 Toll-like Receptor 4 Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Human XCR1+ Dendritic Cells Derived In Vitro from CD34+ Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells

Monocyte-Derived Dendritic Cells Their Adjuvant Responsiveness , Contrary to Resemble Blood Dendritic Cells , Including Progenitors Closely + Vitro from CD 34 Dendritic Cells Derived In + Human XCR

Toll-Like Receptor Ligand Based Adjuvant, PorB, Increases Antigen Deposition on Germinal Center Follicular Dendritic Cells While Enhancing the Follicular Dendritic Cells Network

Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy

Role of natural interferon-producing cells and T lymphocytes in porcine monocyte-derived dendritic cell maturation

IL-27p28 Production by XCR1+ Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8+ T Cell Responses

Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells.

Porcine B Cell Subset Responses to Toll-like Receptor Ligands

TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses.

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

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